Exosomes in atherosclerosis: Convergence on macrophages

Yang, Kaiying; Xiao, Qi; Niu, Mengying; Pan, Xudong; Xiao-yan, Zhu

doi:10.7150/ijbs.71862

Cited by 21 publications

(19 citation statements)

References 151 publications

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“… 180 Macrophages are one of the cells responsible for atherosclerosis; they form foam cells by phagocytosing lipid droplets and accelerating the progression of atherosclerosis. 181 , 182 Basu et al 183 reported that macrophage-specific deletion of RPL13 increases the susceptibility of ApoE knockout mice to high-fat diet-induced atherosclerosis. The protective effect of RPL13 on atherosclerosis may be related to its translational silencing activity: the deletion of RPL13 promotes the translation of mRNAs for CCL22, CXCL13, and CCR3 in macrophages, causing increased expression of inflammatory cytokines.…”

Section: Ribosomes and Cardiovascular Diseases (Cvds)mentioning

confidence: 99%

Ribosome biogenesis in disease: new players and therapeutic targets

Jiao

Liu

et al. 2023

Sig Transduct Target Ther

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The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome biogenesis is the process that generates ribosomes and plays an essential role in cell proliferation, differentiation, apoptosis, development, and transformation. The mTORC1, Myc, and noncoding RNA signaling pathways are the primary mediators that work jointly with RNA polymerases and ribosome proteins to control ribosome biogenesis and protein synthesis. Activation of mTORC1 is required for normal fetal growth and development and tissue regeneration after birth. Myc is implicated in cancer development by enhancing RNA Pol II activity, leading to uncontrolled cancer cell growth. The deregulation of noncoding RNAs such as microRNAs, long noncoding RNAs, and circular RNAs is involved in developing blood, neurodegenerative diseases, and atherosclerosis. We review the similarities and differences between eukaryotic and bacterial ribosomes and the molecular mechanism of ribosome-targeting antibiotics and bacterial resistance. We also review the most recent findings of ribosome dysfunction in COVID-19 and other conditions and discuss the consequences of ribosome frameshifting, ribosome-stalling, and ribosome-collision. We summarize the role of ribosome biogenesis in the development of various diseases. Furthermore, we review the current clinical trials, prospective vaccines for COVID-19, and therapies targeting ribosome biogenesis in cancer, cardiovascular disease, aging, and neurodegenerative disease.

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Section: Ribosomes and Cardiovascular Diseases (Cvds)mentioning

confidence: 99%

Ribosome biogenesis in disease: new players and therapeutic targets

Jiao

Liu

et al. 2023

Sig Transduct Target Ther

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“…After polarization, macrophages secrete not only cytokines but also exosomes with distinct functions. As natural nanoparticles, exosomes have shown high biocompatibility and specific targeting ability, thus being widely employed as imaging agents and drug carriers in recent years [ 73 ]. For example, M1 macrophage-derived exosomes were used as nanoparticle coatings to target drug-resistant and metastatic tumors [ 74 ].…”

Section: Phenotype and Function Of Macrophages Post-mimentioning

confidence: 99%

Crosstalk between macrophages and cardiac cells after myocardial infarction

et al. 2023

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Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death worldwide. Acute MI (AMI) inflicts massive injury to the coronary microcirculation, causing large-scale cardiomyocyte death due to ischemia and hypoxia. Inflammatory cells such as monocytes and macrophages migrate to the damaged area to clear away dead cells post-MI. Macrophages are pleiotropic cells of the innate immune system, which play an essential role in the initial inflammatory response that occurs following MI, inducing subsequent damage and facilitating recovery. Besides their recognized role within the immune response, macrophages participate in crosstalk with other cells (including cardiomyocytes, fibroblasts, immune cells, and vascular endothelial cells) to coordinate post-MI processes within cardiac tissue. Macrophage-secreted exosomes have recently attracted increasing attention, which has led to a more elaborate understanding of macrophage function. Currently, the functional roles of macrophages in the microenvironment of the infarcted heart, particularly with regard to their interaction with surrounding cells, remain unclear. Understanding the specific mechanisms that mediate this crosstalk is essential in treating MI. In this review, we discuss the origin of macrophages, changes in their distribution post-MI, phenotypic and functional plasticity, as well as the specific signaling pathways involved, with a focus on the crosstalk with other cells in the heart. Thus, we provide a new perspective on the treatment of MI. Further in-depth research is required to elucidate the mechanisms underlying crosstalk between macrophages and other cells within cardiac tissue for the identification of potential therapeutic targets.

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“…Atherosclerosis is a chronic and progressive vasculature disease involving inflammation and oxidative stress [59,60]. Endothelial injury and dysfunction result in atherosclerosis and precede lipid deposition, infiltration of immune cells, and accumulation of lipid-rich foam cells [2,61 ].…”

Section: Atherosclerosismentioning

confidence: 99%

Exosomes and lipid metabolism in metabolic and cardiovascular disorders

Abdin¹,

Geng²,

Chandy

2023

Current Opinion in Lipidology

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Purpose of reviewExosomes are lipid-bound particles that carry lipids, protein, and nucleic acid and affect cellular function. This review highlights the current knowledge on the crosstalk between exosomes and lipid metabolism and their impact on cardiometabolic disease.Recent findingsRecent studies revealed that lipids and lipid metabolizing enzymes are important for exosome biogenesis and internalization and conversely how exosomes affect lipid metabolism, secretion, and degradation. The interplay between exosomes and lipid metabolism affects disease pathophysiology. More importantly, exosomes and lipids might function as biomarkers for diagnosis and prognosis or possibly therapies.SummaryRecent advances in our understanding of exosomes and lipid metabolism have implications for our understanding of normal cellular and physiological functions as well as disease pathogenesis. Exosome and lipid metabolism have implications in novel diagnostic tests and treatments of cardiometabolic disease.

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Exosomes in atherosclerosis: Convergence on macrophages

Cited by 21 publications

References 151 publications

Ribosome biogenesis in disease: new players and therapeutic targets

Ribosome biogenesis in disease: new players and therapeutic targets

Crosstalk between macrophages and cardiac cells after myocardial infarction

Exosomes and lipid metabolism in metabolic and cardiovascular disorders

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