IL-27 suppresses RANKL expression in CD4+ T cells in part through STAT3

Kamiya, Sadahiro; Okumura, Masae; Chiba, Yukino; Fukawa, Takeshi; Nakamura, Chika; Nimura, Noriyuki; Mizuguchi, Junichiro; Wada, Seiki; Yoshimoto, Takayuki

doi:10.1016/j.imlet.2011.02.022

Cited by 43 publications

(36 citation statements)

References 42 publications

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“…Besides IL-12Rb2, IL-27 also controls the expression of several other receptors on CD4+ T cells, e. g. the receptor activator of NF-kB ligand (RANKL), which underlines the role of IL-27 in bone destruction [34,35]. IL-27 has also been shown to be critically involved in the control of expression of the pro-inflammatory cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) [36].…”

Section: Role Of Il-27 In the Differentiation Of T Cellsmentioning

confidence: 99%

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The biology of interleukin-27 reveals unique pro- and anti-inflammatory functions in immunity

Aparicio-Siegmund

Garbers

2015

Cytokine & Growth Factor Reviews

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Section: Role Of Il-27 In the Differentiation Of T Cellsmentioning

confidence: 99%

“…In CD4+ and CD8+ T cells, IL-27 suppressed GM-CSF expression, which was independent of IL-2, IL-10 or SOCS3. Whereas expression of RANKL was dependent on STAT3 signaling, the control of GM-CSF expression by IL-27 was dependent on STAT1 [34,36].…”

Section: Role Of Il-27 In the Differentiation Of T Cellsmentioning

confidence: 99%

The biology of interleukin-27 reveals unique pro- and anti-inflammatory functions in immunity

Aparicio-Siegmund

Garbers

2015

Cytokine & Growth Factor Reviews

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“…In collagen-induced arthritis, treatment of mice with IL-27 reduced the severity of arthritis, as well as the levels of IL-6, IL-17 [87] . Another mechanism of IL-27-mediated protection against arthritis involves the inhibition of osteoclastogenesis [191] . It has recently been shown that human Tregs express IL-35 and require this cytokine for their optimal suppressive effect [192] .…”

Section: Il-2 Superfamilymentioning

confidence: 99%

Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications

Magyari

Várszegi

Kövesdi

et al. 2014

WJO

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Rheumatoid arthritis (RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologic targets for RA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics.

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“…Osteoblasts and its precursors also produce cytokines in response to this stimulation (Cornish et al, 2003). The IL-12 family cytokines stimulate T cell responses that subsequently act on osteoclast/osteoblast precursors to promote or suppress cell differentiation (Kamiya et al, 2011). Certain members of the IL-12 family cytokines can also act on osteoclast precursors directly (Chen et al, 2008).…”

Section: Role Of Il-12 Family Cytokine In Regulation Of Inflammatory mentioning

confidence: 99%

“…IL-27 inhibits oseteoclastogensesis through blockade of M-CSF cell signalling via STAT1 dependent mechanisms (Furukawa et al, 2009). CD4 + T cells produce cell surface and soluble RANKL to promote osteoclast formation in joint inflammation (Kamiya et al, 2011). IL-27 suppresses both cell surface and soluble RANKL expressions in CD4 + T cells through suppression of the STAT3 dependent mechanism, rather than STAT1 (Kamiyaet al, 2011).…”

Section: Il-27 Protects Joint From Inflammatory Bone Erosionmentioning

confidence: 99%