IL-21 in the pathogenesis and treatment of skin diseases

Targeting the Binding Interface on a Shared Receptor Subunit of a Cytokine Family Enables the Inhibition of Multiple Member Cytokines with Selectable Target Spectrum

“…IL-15 has also been strongly connected with celiac disease (19 -26). IL-21 (27) is a recent addition and is involved in the differentiation of B and follicular helper T cells (28), which has been implicated in IBD/celiac disease, psoriasis, uveitis (29), atopic dermatitis, systemic lupus erythematosus, multiple sclerosis, and type I diabetes (30,31).…”

Atopic dermatitis - from new pathophysiologic insights to individualized therapy

“…IL-21 exerts its effects on both immune cells and resident cells such as epithelial cells (97). IL-21 was shown to be essential for the maturation of B cells into antibody-secreting plasma cells, to influenced antigen-specific T-cell responses and drive Th17 cell differentiation (97).…”

“…IL-21 was shown to be essential for the maturation of B cells into antibody-secreting plasma cells, to influenced antigen-specific T-cell responses and drive Th17 cell differentiation (97). IL-21 and IL-21 receptor (IL-21R) expression were detected in acute skin lesions of patients with AD, in infiltrating cells and the epidermis, respectively (98).…”

IL-21 and Related Diseases

“…Psoriasis is a multifactorial, immune-mediated chronic skin disease [23,24]. IL-21 is over expressed in the skin of patients with psoriasis and stimulates the proliferation of human keratinocytes.…”

“…Atopic dermatitis (AD) is an inflammatory skin disease with characteristics of eczematous lesions, drying and thickening of the skin, and severe itching [23]. Both IL-21 and IL-21R expressions were upregulated in skin lesions of AD patients [27,28].…”