Atopic dermatitis - from new pathophysiologic insights to individualized therapy

Immunological Reactions in Atopic Dermatitis and Possible Improvement of Probiotics

“…The atopic diseases are chronic inflammatory disorders caused by aberrant T helper 2 (Th2) immune responses against common innocuous environmental antigens in susceptible individuals. The importance of a delicate balance between allergen -specific T-reg cells and allergen-specific Th2 cells in healthy and allergic immune responses to common environmental allergen was demonstrated in study of Atkis et al [8,9].…”

“…IRT5 probiotics, a mixture of 5 probiotics, could suppress diverse immune disorders through the generation of CD4 and administration of IRT5 probiotics suppressed ongoing experimental AD. It is very important to identify potent probiotics that could induce the production of immune-modulatory cytokines such as IL10 and TGFβ or enhancing Th1 response to improve the symptoms of allergic disease [8,10,11]. Perturbation in the intestinal microbiota may disrupt mechanism involved in the development of immunologic tolerance.…”

Expression and Function of CCL17 in Atopic Dermatitis

“…Various exogenous and endogenous factors, including allergens and microbial antigens have been identified as triggers of acute flare ups of the disease as well as risk factors for severe persistent courses (Novak & Simon, 2011). In addition, a multitude of genetic modifications impact on disease manifestation, including a partially genetically predetermined disturbed skin barrier (Barnes, 2010;O'Regan & Irvine, 2010).…”

Thinking Atopic Dermatitis Treatment Differently: Specific Immunotherapy as an Option

“…There is some evidence it might be effective in the treatment of atopic dermatitis in patients with aeroallergen sensitivity. At least 12 placebo controlled trials have been conducted to evaluate the efficacy of SIT in AD patients 40 . A total of 9 trials (75%) reported significant positive effect of SIT in comparison with placebo.…”