IL-2-Dependent ATL cell lines with phenotypes differing from the original leukemia cells

Rapid isolation of viral integration site reveals frequent integration of HTLV-1 into expressed loci

“…The IL-2-dependent, ATLL cell lines OMT, KOB, KK-1, and ST-1 were obtained from Dr. Yamada of Medical School of Nagasaki University Maeda et al 1999;Yamada et al 1991Yamada et al , 1999.…”

The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia

“…Patients with acute type ATL were intensively treated, whereas chronic type ATL patients were observed without chemotherapy before progression to acute type ATL. Three cell lines analyzed in our study were determined to originate from an ATL cell by the rearrangement profiles of the T-cell receptor ␤-chain gene and the integration sites of the HTLV-I proviral DNA identical to the primary ATL cell as described (Yamada et al, 1991). DNA was prepared from mononuclear cells obtained from peripheral blood or cultured cells by a conventional method.…”

Multi-clonal expansion of unique human T-lymphotropic virus type-I-infected T cells with high growth potential in response to interleukin-2 in prodromal phase of adult T cell leukemia

“…In previous reports, IL-2-dependent T cell lines established in bulk liquid culture are usually clonally different from true ATL cells. [25][26][27] These cell lines were considered to be derived from either carrier lymphocytes or normal lymphocytes infected de novo with the virus in vitro. In the present study using clonal cultures, the origin of cell lines clonally distinct from dominant ATL cells, is not clear, but could be explained by one of three possibilities.…”