IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

Ng, Ada Pei Yu; Tam, Wilson Wai San; Zhang, Melvyn W.; Ho, Cyrus S.H.; Husain, Syeda Fabeha; McIntyre, Roger S.; Ho, Roger

doi:10.1038/s41598-018-30487-6

Cited by 422 publications

(281 citation statements)

References 101 publications

(120 reference statements)

Supporting

Mentioning

243

Contrasting

Unclassified

Order By: Relevance

“…Psychopathology was based on self-report questionnaire data and not clinical interview. Previous research found that depression was associated with raised IL-1β levels [61]; the association between PTSD and IL-1β levels found in this study could be confounded by depression. Further research is required to evaluate the effect of pharmacotherapy to reduce IL-1β levels in refugees as previous research found that antidepressants were able to reduce IL-1β levels [62].…”

Section: Discussioncontrasting

confidence: 55%

Inflammation and Trauma-Related Psychopathology in Syrian and Iraqi Refugees

Grasser

Burghardt

Daugherty

et al. 2020

Behavioral Sciences

View full text Add to dashboard Cite

Refugees experience high rates of post-traumatic stress disorder (PTSD), anxiety, and depression due to exposure to civilian war trauma and forced migration. Inflammatory products may offer viable biological indicators of trauma-related psychopathology in this cohort, promoting rapid and objective assessment of psychopathology. Incoming Syrian and Iraqi refugees (n = 36) ages 18-65 completed self-report measures of PTSD, anxiety, and depression and provided saliva samples during an assessment at a primary care clinic within the first month of resettlement in the United States. Interleukin 1β (IL-1β) and C-reactive protein (CRP) differentially correlated with symptom severity by domain, and there was a non-significant trend for sex moderating the relation between inflammation and PTSD symptoms. Our findings show unique relations between trauma-related psychopathology and inflammation. There is a need for further research in diverse ethnic cohorts with differential trauma exposures for inflammation to be considered a biological indicator of psychopathology.

show abstract

Section: Discussioncontrasting

confidence: 55%

Inflammation and Trauma-Related Psychopathology in Syrian and Iraqi Refugees

Grasser

Burghardt

Daugherty

et al. 2020

Behavioral Sciences

View full text Add to dashboard Cite

show abstract

“…COVID-19 can cause acute respiratory syndrome with consequent release of pro-inflammatory cytokines, including interleukin (IL)-1β and IL-6 from the respiratory tract. 22 These cytokines were commonly found to be increased in major depressive disorder 23,24 and functional somatic syndromes 25 . COVID-19, depression and functional somatic syndrome share the same PNI framework.…”

Section: Discussionmentioning

confidence: 99%

A longitudinal study on the mental health of general population during the COVID-19 epidemic in China

Wang

Pan

Wan

et al. 2020

Brain, Behavior, and Immunity

Self Cite

2,250

245

2,175

View full text Add to dashboard Cite

In addition to being a public physical health emergency, Coronavirus disease 2019 affected global mental health, as evidenced by panic-buying worldwide as cases soared.Little is known about changes in levels of psychological impact, stress, anxiety and depression during this pandemic. This longitudinal study surveyed the general population twice -during the initial outbreak, and the epidemic's peak four weeks later, surveying demographics, symptoms, knowledge, concerns, and precautionary measures against COVID-19. There were 1738 respondents from 190 Chinese cities (1210 first-survey respondents, 861 second-survey respondents; 333 respondents participated in both). Psychological impact and mental health status were assessed by the Impact of Event Scale-Revised (IES-R) and the Depression, Anxiety and Stress Scale (DASS-21), respectively. IES-R measures PTSD symptoms in survivorship after an event. DASS -21 is based on tripartite model of psychopathology that comprise a general distress construct with distinct characteristics. This study found that there was a statistically significant longitudinal reduction in mean IES-R scores (from 32.98 to 30.76, p<0.01) after 4 weeks. Nevertheless, the mean IES-R score of the first-and secondsurvey respondents were above the cut-off scores (>24) for PTSD symptoms, suggesting that the reduction in scores was not clinically significant. During the initial evaluation, moderateto-severe stress, anxiety and depression were noted in 8.1%, 28.8% and 16.5%, respectively and there were no significant longitudinal changes in stress, anxiety and depression levels (p>0.05). Protective factors included high level of confidence in doctors, perceived survival likelihood and low risk of contracting COVID-19, satisfaction with health information, personal precautionary measures. As countries around the world brace for an escalation in cases, Governments should focus on effective methods of disseminating unbiased COVID-19 knowledge, teaching correct containment methods, ensuring availability of essential services/commodities, and providing sufficient financial support. 4

show abstract

“…Several studies have investigated whether peripheral IL-6 levels are significantly higher in the elderly with depression. Ng et al carried out a meta-analysis of nine studies to evaluate whether peripheral IL-6 levels are significantly higher in elderly with depression [49]. They found, compared with controls, IL-6 were significantly elevated in the aged depression subjects.…”

Section: Il-6 and Depression Subtypesmentioning

confidence: 99%

Role of Interleukin-6 in Depressive Disorder

Ting

Yang

Tsai

2020

IJMS

226

152

View full text Add to dashboard Cite

Major depressive disorder (MDD), which is a leading psychiatric illness across the world, severely affects quality of life and causes an increased incidence of suicide. Evidence from animal as well as clinical studies have indicated that increased peripheral or central cytokine interleukin-6 (IL-6) levels play an important role in stress reaction and depressive disorder, especially physical disorders comorbid with depression. Increased release of IL-6 in MDD has been found to be a factor associated with MDD prognosis and therapeutic response, and may affect a wide range of depressive symptomatology. However, study results of the IL6 genetic effects in MDD are controversial. Increased IL-6 activity may cause depression through activation of hypothalamic-pituitary-adrenal axis or influence of the neurotransmitter metabolism. The important role of neuroinflammation in MDD pathogenesis has created a new perspective that the combining of blood IL-6 and other depression-related cytokine levels may help to classify MDD biological subtypes, which may allow physicians to identify the optimal treatment for MDD patients. To modulate the IL-6 activity by IL-6-related agents, current antidepressive agents, herb medication, pre-/probiotics or non-pharmacological interventions may hold great promise for the MDD patients with inflammatory features.

show abstract

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

Cited by 422 publications

References 101 publications

Inflammation and Trauma-Related Psychopathology in Syrian and Iraqi Refugees

Inflammation and Trauma-Related Psychopathology in Syrian and Iraqi Refugees

A longitudinal study on the mental health of general population during the COVID-19 epidemic in China

Role of Interleukin-6 in Depressive Disorder

Contact Info

Product

Resources

About