IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells

Aoi, Noriko; Masuda, Takanobu; Murakami, Daisuke; Yajima, Toshiki; Mizubuchi, Hiroyuki; Yamada, Hisakata; Kawauchi, Hideyuki; Yoshikai, Yasunobu

doi:10.1016/j.jaci.2006.02.018

Cited by 17 publications

(18 citation statements)

References 36 publications

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“…At present, B‐cell‐targeted therapies in chronic autoimmune urticaria are caused increasingly by autoantibodies, which may be a more direct and effective therapy than neutralizing IgE with the hope of downregulating FcεRI expression 40 . Moreover, IL‐15 and IL‐21 are used in treatment of allergic diseases with certain effect 15,41 . On the basis of these results, we propose that the design of successful therapy for urticaria may target a regulatory pathway linking B cells, T cells, IgE, IL‐15 and IL‐21.…”

Section: Discussionmentioning

confidence: 99%

Role of the subgroups of T, B, natural killer lymphocyte and serum levels of interleukin‐15, interleukin‐21 and immunoglobulin E in the pathogenesis of urticaria

Zhu

Liang

et al. 2010

The Journal of Dermatology

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The immunological characterization in the pathogenesis of urticaria, mainly regarding cytokine profile, needs more investigation. In this study, subgroups of the T, B and natural killer (NK) lymphocyte from peripheral blood and serum levels of interleukin (IL)-15, IL-21 and immunoglobulin (Ig)E were examined in patients with acute urticaria (AU) and chronic urticaria (CU). Moreover, symptom scores and course of the patients were assessed. The percentage of NK cells and the ratio of CD4(+)/CD8(+) increased, however, CD8(+) decreased in CU compared to controls (P < 0.01). But no significant changes of T, B and NK lymphocyte were found in AU. IL-15 and IL-21 significantly decreased in AU and CU, but IgE increased. CU with a positive autologous serum skin test were more likely to be associated with longer course and higher CD3(+), B cells and IL-21, and lower IgE (P < 0.01). Weak negative correlations were demonstrated between CD3(+), CD8(+) and scores in CU (r = -0.23, -0.25, P < 0.05). Significant correlations were found between B cells and scores and course in CU (r = 0.49, 0.65, P < 0.01). Moreover, a significant correlation was found between IL-21 and IgE (r = 0.42, P < 0.01) in CU. But no significant correlations were found in AU. Our findings supported the concept that both humoral immunity and cellular immunity dysregulation in the pathogenesis of urticaria - mainly related to the decrease of the serum levels of IL-15 and IL-21 - may induce the increasing expression of IgE produced by B cells.

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Section: Discussionmentioning

confidence: 99%

Role of the subgroups of T, B, natural killer lymphocyte and serum levels of interleukin‐15, interleukin‐21 and immunoglobulin E in the pathogenesis of urticaria

Zhu

Liang

et al. 2010

The Journal of Dermatology

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“…[1][2][3]7 Positive correlations between CCL11 levels and the final EDSS and Sensory FS scores, and between IL-9 levels and the final EDSS scores, suggest that the IL-9/CCL11 axis contributes to tissue damage in AM, in which sensory impairment predominates due to preferential involvement of the posterior column. Since IL-15 promotes IFN-␥ production from Th1 cells 25 and prevents allergic rhinitis, 26 downregulation of IL-15 could also be a reflection of the Th2-dominant state in AM.…”

Section: Statistical Analysis Statistical Analyses Of Cytokine Levelmentioning

confidence: 99%

Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis

Tanaka

Matsushita²,

Tateishi

et al. 2008

Neurology

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“…16 IL-15 knockout mice responded to nasal allergen challenge with increased sneezing, infiltration of eosinophils, and T H 2 cytokine production compared with controls. Adoptive transfer of CD8 1 T cells from sensitized mice to control mice suppressed the T H 2 responses but was ineffective in IL-15 knockout mice.…”

Section: Mechanisms Of Rhinitismentioning

confidence: 94%

Advances in upper airway diseases and allergen immunotherapy

Nelson

2007

Journal of Allergy and Clinical Immunology

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IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells

Cited by 17 publications

References 36 publications

Role of the subgroups of T, B, natural killer lymphocyte and serum levels of interleukin‐15, interleukin‐21 and immunoglobulin E in the pathogenesis of urticaria

Role of the subgroups of T, B, natural killer lymphocyte and serum levels of interleukin‐15, interleukin‐21 and immunoglobulin E in the pathogenesis of urticaria

Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis

Advances in upper airway diseases and allergen immunotherapy

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