2017
DOI: 10.4049/jimmunol.1601018
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IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections

Abstract: IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. Staphylococcus aureus has previously been shown to manipulate the IL-10 response as a mechanism of immune evasion during chronic systemic and biofilm models of infection. In the present study, we demonstrate divergent roles for IL-10 depending on the site of infection. During acute systemic S. aureus infection, IL-10 plays an important pr… Show more

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Cited by 69 publications
(63 citation statements)
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“…While IL-17 can recruit neutrophils, IL-10 may neutralize TNF-α, attenuate tissue pathology, and reduce mortality (37). In addition, the balance between the IL-10 and IL-17 cytokines is also crucial for bacterial elimination and protecting the host from a pathological condition at the site of infection (38,39). These results depict a picture that DFT peptides play a critical role in eliminating S. aureus USA300 via direct killing as well as immune boosting both in vitro and in vivo.…”
Section: Mechanism Of Action and Structural Basis Of Cell Selectivitymentioning
confidence: 99%
“…While IL-17 can recruit neutrophils, IL-10 may neutralize TNF-α, attenuate tissue pathology, and reduce mortality (37). In addition, the balance between the IL-10 and IL-17 cytokines is also crucial for bacterial elimination and protecting the host from a pathological condition at the site of infection (38,39). These results depict a picture that DFT peptides play a critical role in eliminating S. aureus USA300 via direct killing as well as immune boosting both in vitro and in vivo.…”
Section: Mechanism Of Action and Structural Basis Of Cell Selectivitymentioning
confidence: 99%
“…It is known that in the absence of effective microbial decontamination, prolonged inflammation may enter a chronic state prone to failure to heal . While IL‐10 plays an important protective role and is required to prevent bacterial spread, S aureus has previously been shown to manipulate the IL‐10 response as a mechanism of immune evasion during chronic systemic and biofilm models of infection . The interactions between S aureus and IL‐10 promotion are complex, and further studies need to be undertaken.…”
Section: Discussionmentioning
confidence: 99%
“…The interactions between S aureus and IL‐10 promotion are complex, and further studies need to be undertaken. A high level of IL‐10 may facilitate bacterial persistence, whereas a low level of IL‐10 may cause excessive activation of immune cells and lead to fatal host‐mediated damages or bacterial superinfections . Since these cytokines may also facilitate the tissue‐healing process in injuries caused by infection or inflammation, they could be explored as an anti‐scarring therapeutic agent with potential application in the treatment of infected wound, associated with topical antimicrobial agents.…”
Section: Discussionmentioning
confidence: 99%
“…IL-10 contributes in pathologic events during acute localized S. aureus infection by inhibiting local proinflammatory cytokine production. However, during the acute systemic S. aureus infection, IL-10 via the same mechanism protects the host by controlling immunopathologic responses [126]. These findings represent that TLR2-related IL-10 production may play different or even opposing roles during systemic and localized S. aureus infections.…”
Section: Accepted Manuscriptmentioning
confidence: 95%
“…Staphylococcus aureus (S. aureus) induces the production of IL-10 by monocytes, macrophages and B1a cells in a TLR2-dependent manner [125,126]. IL-10 contributes in pathologic events during acute localized S. aureus infection by inhibiting local proinflammatory cytokine production.…”
Section: Accepted Manuscriptmentioning
confidence: 99%