IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells

Cianciulli, Antonia; Dragone, Teresa; Calvello, Rosa; Porro, Chiara; Trotta, Teresa; Lofrumento, Dario Domenico; Panaro, Maria Antonietta

doi:10.1016/j.intimp.2014.12.035

Cited by 103 publications

(66 citation statements)

References 64 publications

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“…IL-10 is an anti-inflammatory and immunoregulatory cytokine. Several studies have demonstrated that IL-10 inhibited the production of pro-inflammatory cytokines by reactive glia in response to LPS (Bozic et al, 2015;Cianciulli et al, 2015;Molina-Holgado et al, 2001;Szczepanik et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Delayed activation of human microglial cells by high dose ionizing radiation

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Delayed activation of human microglial cells by high dose ionizing radiation

et al. 2016

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“…Microglia is the main immune cells in the brain [15]. Microglia can be activated by LPS or other agents and activated microglia release inflammatory mediators such as TNF-a, IL-1ß, NO and PGE 2 [16]. Previous studies indicated that inhibition of inflammatory mediators production could attenuate the severity of neurodegenerative diseases [17,18].…”

Section: Discussionmentioning

confidence: 99%

Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2

Zhou

et al. 2015

Neurochem Res

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Linalool, a natural compound of the essential oils, has been reported to have anti-inflammatory effects. This study aimed to investigate the anti-inflammatory effects and mechanism of linalool in LPS-stimulated BV2 microglia cells. BV2 microglia cells were stimulated with LPS in the presence or absence of linalool. The production of inflammatory mediators TNF-α, IL-1β, NO, and PGE2 as well as Nrf2, HO-1 expression were detected. Our results showed that linalool inhibited LPS-induced TNF-α, IL-1β, NO, and PGE2 production in a dose-dependent manner. Linalool also inhibited LPS-induced NF-κB activation. Treatment of linalool induced nuclear translocation of Nrf2 and expression of HO-1. In addition, our results showed that the anti-inflammatory effect of linalool was attenuated by transfection with Nrf2 siRNA. In conclusion, these results suggested that linalool inhibits LPS-induced inflammation in BV2 microglia cells by activating Nrf2/HO-1 signaling pathway.

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“…Moreover, resveratrol, a natural polyphenol reported to have anti-inflammatory effects, is able to up-regulate both IL-10 gene expression and IL-10 levels, which could explain its neuroprotective properties 32 . Bagyinszky et al 22 disclosed that IL-10 treatment could be a potential therapy for AD since this cytokine could act on amyloid reduction by inducing the production of anti-inflammatory molecules, and inhibition of pro-inflammatory cytokines, probably by down-regulating their expression.…”

Section: Alzheimer's Disease and Il-10 Effectsmentioning

confidence: 99%

“…According to them, inconsistent outcomes involve IL-10: this cytokine drives macrophage polarization -M1 to M2, which is associated with deactivation of microglia; overexpressing tau increases secretion of IL-10 in rat microglia, which show greater phagocytosis of microspheres; knockout mice show the benefit of IL-10 removal 32 . However, some meta-analysis studies have not found significant differences in IL-10 levels between subjects with mild cognitive impairment (MCI) and healthy controls.…”

Section: Alzheimer's Disease and Il-10 Effectsmentioning

confidence: 99%

Alzheimer’s disease and cytokine IL-10 gene polymorphisms: is there an association?

Magalhães

Carvalho

Sousa

et al. 2017

Arq. Neuro-Psiquiatr.

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Alzheimer’s disease (AD) is the most common form of dementia. In the last 15 years, a new theory has proposed the autoimmune mechanism as a trigger for AD. Studies on the association between AD and inflammatory biomarkers have yielded controversial results. Interleukin-10 (IL-10), an anti-inflammatory mediator, has been pointed out as one of the main cytokines associated with the occurrence of AD. Moreover, treatment that increases IL-10 levels could be a potential therapy for AD, since this cytokine acts on amyloid and pro-inflammatory molecule reduction. Based on the current literature, this study reviews evidence regarding the role of IL-10 polymorphisms in the context of AD, which has been shown to be of paramount importance for attenuating neuroinflammation, cognitive dysfunction and neurodegeneration.

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IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells

Cited by 103 publications

References 64 publications

Delayed activation of human microglial cells by high dose ionizing radiation

Delayed activation of human microglial cells by high dose ionizing radiation

Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2

Alzheimer’s disease and cytokine IL-10 gene polymorphisms: is there an association?

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