IL‐10 gene polymorphism, but not TGF‐β1 gene polymorphisms, is associated with food allergy in a Japanese population

Abstract

The regulatory IL-10 and TGF-beta1 cytokine gene polymorphisms have been associated with allergic diseases in different populations, like Caucasian, Chinese and Indians. We investigated the association between the polymorphisms IL-10 A-1082G, C-819T, C-627A and TGF-beta1 T+869C, G+915C, C-509T and food allergy in Japanese children. One hundred and eleven children with food allergy and 115 atopic control children without food allergy were recruited. DNA samples from these subjects were genotyped by using PCR. The odds ratio of IL-10 -1082 AA genotype was 2.5 (95% CI, 1.0-6.4) for food allergy risk when compared with atopic control subjects (p = 0.03). There were no significative differences in the frequency of TGF-beta1 gene polymorphisms between both groups. Our results indicate that IL-10 A-1082G gene polymorphism is associated with food allergy susceptibility in atopic Japanese children.

Association between human IL-10 gene polymorphisms and serum IL-10 level in patients with food allergy

“…The two IL-10 SNP genotype frequencies studied in the controls are similar to those observed in Chinese and Japanese populations, who are ethnically close to Taiwanese. 6,14,15 The frequencies of the G allele and GG genotype of the IL-10 Ae1082 G polymorphism in Caucasians are higher, 8,16 whereas the GG genotype is not found in Taiwanese.…”

“…14 They also noted that genotype AA was significantly associated with higher IgE levels in serum. A case-control association study 6 suggested that the IL-10 e1082 A/G gene polymorphism is related to FA susceptibility in atopic Japanese children. However, the functional relationship of IL-10 gene polymorphisms in FA have not been investigated clearly.…”

“…Several important polymorphic sites in the IL-10 gene have been reported, including three in the promoter region (-1082 A/G, -819 T/C, e592 A/C) that control transcription and may influence the transcription of IL-10 messenger RNA and IL-10 expression in vitro. 5 A case-control association study 6 suggested that the IL-10 e1082A/G gene polymorphism is related to FA susceptibility in atopic Japanese children. However, the functional relationship of IL-10 gene polymorphisms in FA has not been investigated in detail.…”

Update on risk factors for food allergy

“…21 Recently, an IL10 gene polymorphism has been associated with FA in a Japanese population, 22 and an IL13 polymorphism has been identified in association with FA in another study. 23 These studies will need to be replicated in different populations.…”

Epidemiologic risks for food allergy

“…A signal transducer and activator of transcription 6 polymorphism has been shown to be associated with nut allergies in one study. 10 Recently, an IL10 gene polymorphism has been associated with food allergy in a Japanese population, 11 and an IL13 polymorphism has been identified in association with food allergy in another study. 12 These studies will need to be replicated in different populations.…”