IL‐1 RN 2/2 genotype and simultaneous carriage of genotypes IL‐1 RN 2/2 and IL‐1β‐511 T/T associated with oesophagitis in Helicobacter pylori‐negative patients

Koivurova, Olli-Pekka; Karhukorpi, Jari; Joensuu, E. T.; Koistinen, P.; Valtonen, Jarno; Karttunen, Tuomo J.; Niemelä, Seppo; Karttunen, Riitta

doi:10.1080/00365520310006504

Cited by 20 publications

(21 citation statements)

References 37 publications

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“…In our study, we found that the combination, IL1B −31T and IL1RN 1.1, was associated with increased risk of NSCLC. Similar to gastric cancer, simultaneous carriage of IL1RN 2.2 and IL1B −511 T/T was found in strong association with oesophagitis in Helicobacter pylori-negative patients [35]. Rapid decline of lung function among smokers was found to be associated with carriage of the haplotype IL1B −511T/IL1RN*1 [25].…”

Section: Discussionmentioning

confidence: 95%

Interleukin 1 receptor antagonist gene polymorphism and risk of lung cancer: A possible interaction with polymorphisms in the interleukin 1 beta gene

et al. 2005

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Section: Discussionmentioning

confidence: 95%

Interleukin 1 receptor antagonist gene polymorphism and risk of lung cancer: A possible interaction with polymorphisms in the interleukin 1 beta gene

et al. 2005

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“…Among healthy persons, important inter-individual variations were seen in pro-inflammatory proteins especially in in-vitro production (9). Numerous reseraches have shown the impact of polymorphisms of IL-1β and IL-1RN on the development of GERD (16). As different patterns are observed among the patients from India (10), Japan (11), it is estimated that there Table 3.…”

Section: Discussionmentioning

confidence: 99%

The role of interleukin-1 gene polymorphisms and Helicobacter pylori in gastroesophageal reflux disease

Akcil

Doğan²,

Cengiz³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Our aim is to assess the relationship between interleukin 1β (IL-1 β), (-511,-31 alleles), interleukin 1RN (IL-RN), Helicobacter pylori (HP) status and gastroesophageal reflux disease (GERD) diagnosed by pH monitoring in the Turkish population. Materials and Methods: A Total of 100 consecutive patients with GERD were enrolled in the study. Genotypes of IL-1β (-511,-31), IL-1RN gene polymorphisms and HP status of the patients were analyzed. Results: While thirty-two patients were diagnosed as esophagitis with varying severity the remaining patients had no esophagitis. Seventy six participants were positive for HP and the remaining patients were negative. The difference between erosive and non-erosive groups was statistically significant when we compared IL-1β (-511) but no difference regarding IL-1β (-31) and IL-1RN variations. We also analyzed T/T, C/T and C/C alleles and the difference was significant statistically in T/T allele between patients with and without erosive GERD 1 (3.1%) vs. 12 (17.9%), respectively with a p value <0.05. But C/C, C/T alleles of (-511), (-31) and IL-1RN polymorphisms were not statistically significant between the groups. Conclusion: IL-1β genetic polymorphisms may take part in the pathophysiology of gastroesophageal reflux disease.

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“…Koivurova et al (23) reported that the simultaneous carriage of those two polymorphisms is significantly associated with esophagitis. Garcia-Gonzalez et al (24) confirmed that the same IL-1B and IL-1RN polymorphisms that are associated with high risk of distal gastric adenocarcinoma are associated with a reduced risk of duodenal ulcer.…”

Section: Interactions Of Il-1b Polymorphisms With Other Diseasesmentioning

confidence: 99%

Role of Cytokine Polymorphisms in the Risk of Distal Gastric Cancer Development

Pérez-Pérez¹,

Garza‐González

Portal

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We review the current information concerning the role of cytokine polymorphisms and the risk of develop distal gastric cancer in different populations. We have included populations colonized with Helicobacter pylori as well as populations without colonization. We found that the study of polymorphisms alone seems insufficient to assess gastric cancer risk and it is necessary to examine environmental factors in different ethnic groups and geographic areas along with the study of H. pylori strains to define better the risk factors associated with distal gastric cancer. (Cancer Epidemiol Biomarkers Prev 2005;14(8):1869 -73)

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IL‐1 RN 2/2 genotype and simultaneous carriage of genotypes IL‐1 RN 2/2 and IL‐1β‐511 T/T associated with oesophagitis in Helicobacter pylori‐negative patients

Abstract: The results indicate that the IL-1RN 2/2 genotype and the carriage of combined genotypes IL-1RN 2/2 + IL-1beta-511 T/T are associated with H. pylori-negative oesophagitis. This is the first report on the association between IL-1 gene polymorphism and oesophagitis.

Cited by 20 publications

References 37 publications

Interleukin 1 receptor antagonist gene polymorphism and risk of lung cancer: A possible interaction with polymorphisms in the interleukin 1 beta gene

Interleukin 1 receptor antagonist gene polymorphism and risk of lung cancer: A possible interaction with polymorphisms in the interleukin 1 beta gene

The role of interleukin-1 gene polymorphisms and Helicobacter pylori in gastroesophageal reflux disease

Role of Cytokine Polymorphisms in the Risk of Distal Gastric Cancer Development

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