IKZF1 Rs4132601 Polymorphism and Susceptibility to Acute Lymphocytic Leukemia in Children: A Meta-analysis

Abstract

Background: Many studies have shown that IKAROS family zinc finger 1 (IKZF1) rs4132601 polymorphism is strongly linked to acute lymphoblastic leukemia (ALL) in children, but their conclusions have been inconsistent.Objective: This meta-analysis is set out to investigate the association between IKZF1 rs4132601 polymorphism and its susceptibility to childhood ALL.Data and Methods: On the basis of inclusion criteria, PubMed, EMBASE, Web of Science, CNKI, China Wanfang, VIP, and other databases were searched from the time of the establishment of the library database to December 2019 for all case-control studies. Stata 15.0 was applied for meta-analysis to calculate the combined odds ratio (OR) value and 95% confidence interval (CI) of each genotype at IKZF1 rs4132601. Subgroup analysis done by ethnicity, sensitivity analysis, and publication bias assessment was further performed.Results: Nine pieces of literature was included in this meta-analysis, including 2281 children with ALL and 2923 controls. There were significant differences in the allelic model (T vs. G: combined OR = 0.75, 95% CI: 0.68-0.82, P < 0.05) in both Asian and Caucasian children. In addition to this, there were statistically significant differences in the dominant, homozygous and heterozygous genetic model in both Asian and Caucasian children. The difference was significant in the recessive genetic model (TT vs. TG+GG: combined OR = 0.75, 95% CI: 0.67-0.84) in Caucasian children, but not in Asian children (combined OR = 0.85, 95% CI: 0.70-1.04, P > 0.05). Conclusion:There is a strong correlation between IKZF1 rs4132601 polymorphism and ALL in children. Compared with the G allele, T alleles can lower the risk of childhood ALL, and TT, TT+TG and TG genotypes can also reduce the risk of ALL in children.

The role of TNF-α (rs1800629) ve IKZF1 (rs4132601) gen polimorphisms in pathogenesis of Hodgkin’s lymphoma

“…18 Wu ve arkadaşlarının yaptığı, ALL tanılı 2281 çocuk ve 2923 kontrol grubundan oluşan çalışmada G alleli ile karşılaştırıldığında, T alleline ve dolayısıyla TT ile TG genotipine sahip olan çocuklarda ALL riskinin daha az olduğu bildirilmiştir. 19 Çalışmamız da, IKZF1 (rs4132601) polimorfizminin HL için bir risk faktörü olduğu düşüncesini desteklemektedir.…”