II. Über eine genitale Influenzainfektion bei einer Gebärenden als Ursache eines Puerperalfiebers

Thaler, H; Zuckermann, Hans

doi:10.1159/000291681

Cited by 7 publications

(3 citation statements)

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“…It has been suspected for many years that Haemophilus spp. play a role in gynecologic and obstetric infections (8)(9)(10), and from recent studies it appears that they are potential genital pathogens (11)(12)(13)(14)(15). It is therefore important toknowthe frequency andorigin of genital contamination with these organisms.…”

Section: Resultsmentioning

confidence: 99%

Distribution ofHaemophilus influenzae andHaemophilus parainfluenzae biotypes isolated from the human genitourinary tract

Drouet

Denoyel

Boude

et al. 1989

Eur. J. Clin. Microbiol. Infect. Dis.

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A total of 3,598 genital specimens from men and women was cultured for Haemophilus spp. using a simple selective culture method. Two hundred and thirty three samples (6.5%) were positive for Haemophilus spp., 216 Haemophilus parainfluenzae and 28 Haemophilus influenzae strains being isolated. Biotyping demonstrated that Haemophilus parainfluenzae biotype II was dominant at all sites, especially the male urethra, comprising 59% of all Haemophilus strains isolated. On the other hand, Haemophilus influenzae biotype IV was isolated from only six patients and thus was not a major genital biotype. The respective proportions of the two Haemophilus spp. recovered from various mucosal sites led to the supposition that the genitourinary colonization originated either from the upper respiratory tract or the gastrointestinal tract.

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Section: Resultsmentioning

confidence: 99%

Distribution ofHaemophilus influenzae andHaemophilus parainfluenzae biotypes isolated from the human genitourinary tract

Drouet

Denoyel

Boude

et al. 1989

Eur. J. Clin. Microbiol. Infect. Dis.

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“…Genital, perinatal, and neonatal infections due to Haemophilus strains were first described in the early 1900s (5,14,27). The number of reported cases has increased in the last 20 years (7,13,14,22,28).…”

Section: Discussionmentioning

confidence: 99%

Genetic identification of cryptic genospecies of Haemophilus causing urogenital and neonatal infections by PCR using specific primers targeting genes coding for 16S rRNA

et al. 1996

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Previous genetic analysis of Haemophilus influenzae strains isolated from genital and neonatal infections identified a group of biotype IV that constitutes a cryptic genospecies only distantly related to H. influenzae and H. haemolyticus. Small-subunit rRNA genes of two representative strains of this genital Haemophilus genospecies (strains 16N and 2406) were sequenced. The analysis indicated that these strains form a monophyletic unit with H. haemolyticus and H. influenzae biogroups Influenzae and Aegyptius and are more closely related to H. haemolyticus than to H. influenzae biogroups Influenzae and Aegyptius. 16S rRNA gene sequences were used to formulate primers for PCR-based identification of cryptic genital Haemophilus organisms. A 242-bp fragment was amplified from strains belonging to the genital Haemophilus genospecies but not from strains of 12 other Haemophilus species, including strains of H. influenzae biotype IV sensu stricto.

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“…The first neonatal, perinatal, and genital infections due to Haemophilus strains were described in the early 1900s (22,40,66), but the number of cases, while remaining low, has increased only in the last 15 years (3,10,16,20,37,58,72). A specific tropism of some Haemophilus influenza strains to the genital tract has been suggested from biotyping and serotyping studies (2,58,72); this is not unanimously admitted (41).…”

mentioning

confidence: 99%

Typing of urogenital, maternal, and neonatal isolates of Haemophilus influenzae and Haemophilus parainfluenzae in correlation with clinical source of isolation and evidence for a genital specificity of H. influenzae biotype IV

et al. 1989

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Over a period of 6 years, 114 strains of Haemophilus influenza and Haemophilus parainfluenzae were isolated from genital, mother-infant, or neonatal infections. Their serotypes, biotypes, antibiotic resistance phenotypes, and outer membrane protein (OMP) electrophoretic patterns were characterized and correlated with the various clinical outcomes. Genital H. influenza and H. parainfluenzae appeared to behave mostly as opportunistic pathogens; for instance, 62% of the cases of endometritis or pelvic inflammatory disease were related to the presence of an intrauterine device. However, as seen clearly in one case, the strains may be sexually transmitted. The analysis of OMP patterns proved to be a very convenient method to seek evidence for the sexual origin of the infection. H. influenzae was more often involved in complicated genital infections than was H. parainfluenzae. Nontypeable and biotype II H. injluenzae strains were the more frequent isolates, except in pelvic inflammatory diseases, in which biotype I prevailed, and in mother-infant infections, in which one-fourth of the cases were due to biotype IV. Characterization of H. influenzae isolates did not support a general concept of specific genital strains. However, strains of biotype IV clearly stood out with two characteristics: (i) a peritrichous fimbriation and (ii) a very peculiar homogeneous OMP pattern comprising an OMP of molecular weight '18,000 unique to this biotype. These characteristics were also found in H. influenza biotype IV strains isolated from genital infections in the United States and used as controls. H. influenza biotype IV strains may thus correspond to a group somewhat adapted to the genital tract. * Corresponding author. mostly from neonatal or mother-infant infections in the United States and France (58, 72). However, clinical outcome has been shown to be more severe in Houston, Tex. (72), than in Tours, France (58). To account for this difference, we have compared our own H. influenza biotype IV isolates to nine strains originating in the United States and kindly provided by R. J. Wallace. MATERIALS AND METHODS Patients. Haemophilus spp. were isolated from 1 October 1979 through 31 March 1987 in patients from the Centre Hospitalier Régional et Universitaire Bretonneau in Tours, France. Patients belonged to two groups: women consulting for genital or urinary tract infections and newborn infants suspected to be at risk of infection on the basis of clinical signs in the mother (fever, genital or urinary tract infections, premature rupture of membranes, or premature onset of labor) or overt clinical signs in the child (fever, respiratory distress syndrome, shock, jaundice, or leukopenia). In these cases, bacterial investigations included two placental smears corresponding to both sides of the placenta, an aspiration of the gastric fluid, and swabs of ears, mouth, anus, and nose. In addition, urine analysis, blood cultures, and lumbar punctures were carried out in three circumstances: when the neonate had clinical or biological signs ...

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II. Über eine genitale Influenzainfektion bei einer Gebärenden als Ursache eines Puerperalfiebers

Cited by 7 publications

References 0 publications

Distribution ofHaemophilus influenzae andHaemophilus parainfluenzae biotypes isolated from the human genitourinary tract

Distribution ofHaemophilus influenzae andHaemophilus parainfluenzae biotypes isolated from the human genitourinary tract

Genetic identification of cryptic genospecies of Haemophilus causing urogenital and neonatal infections by PCR using specific primers targeting genes coding for 16S rRNA

Typing of urogenital, maternal, and neonatal isolates of Haemophilus influenzae and Haemophilus parainfluenzae in correlation with clinical source of isolation and evidence for a genital specificity of H. influenzae biotype IV

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