IgM rheumatoid factor and low molecular weight IgM. An association with vasculitis

Theofilopoulos, Argyrios N.; Burtonboy, Guy; LoSpalluto, Joseph; Ziff, Morris

doi:10.1002/art.1780170312

Cited by 116 publications

(21 citation statements)

References 50 publications

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“…This was not the case, since both IgM and IgA, as well as complement cleavage products, were detected in varying degrees in association with the IgG in these lower molecular weight fractions. It is reasonable to speculate that the IgM in the lower molecular weight fractions represents 7s IgM, which is well described in chronic inflammatory diseases, including adult rheumatoid arthritis (26)(27)(28). Previous observations from this laboratory also support the presumption that at least some of the IgA and IgM detected within the high molecular weight complexes represents IgA-RF and IgM-RF (29).…”

Section: Discussionsupporting

confidence: 60%

In vitro induction of proinflammatory cytokine secretion by juvenile rheumatoid arthritis synovial fluid immune complexes

Jarvis

Wang

Moore

et al. 1997

Arthritis & Rheumatism

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Objective. To characterize juvenile rheumatoid arthritis synovial fluid (SF) immune complexes and to examine their interaction with leukocytes. Methods. SF immunoglobulin‐containing fractions were prepared by sequential chromatography on protein A and Sephacryl 300. Fractions were subdivided according to molecular weight, characterized for immunoglobulin and complement content, and incubated with either promonocytic U937 cells or normal human peripheral blood mononuclear cells (PBMC). Results. High molecular weight SF immunoglobulin‐containing fractions stimulated the release of interleukin‐lβ (IL‐1β) from U937 cells. These same complexes stimulated tumor necrosis factor α (TNFα), IL‐lβ, IL‐6, IL‐8, and granulocytemacrophage colony‐stimulating factor (GM‐CSF) from PBMC. Lower molecular weight material was less efficient in inducing any of the cytokines. TNFα and IL‐1β were the earliest of the messenger RNAs examined to be induced by the high molecular weight complexes. However, the secretion of IL‐6, IL‐8, and GM‐CSF stimulated by the complexes was not completely dependent upon the secretion of IL‐1β. Addition of IL‐1 receptor antagonist to the cell cultures reduced GM‐CSF and IL‐6 production by 40% and IL‐8 production by 25% in PBMC. Conclusion. SF immunoglobulin fractions contain immune complexes that vary in size, composition, and phlogistic potential. High molecular weight complexes are capable of inducing a spectrum of proinflammatory cytokines, all of which have been implicated in the pathogenesis of rhematic disease.

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Section: Discussionsupporting

confidence: 60%

In vitro induction of proinflammatory cytokine secretion by juvenile rheumatoid arthritis synovial fluid immune complexes

Jarvis

Wang

Moore

et al. 1997

Arthritis & Rheumatism

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“…The presence of high-titer IgG-and IgM-RF has been associated with vasculitis in RA (30,31). Similarly, the presence of RF has been associated with clinical vasculitis in SLE (32).…”

Section: Discussionmentioning

confidence: 99%

Two types of inflammatory vascular disease in Sjögren's syndrome. Differential association with seroreactivity to rheumatoid factor and antibodies to Ro (SS‐A) and with hypocomplementemia

Molina

Provost

Alexander

1985

Arthritis & Rheumatism

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Two types of inflammatory vascular disease (IVD) occur in Sjogren's syndrome: neutrophilic IVD (NIVD) and mononuclear IVD (MIVD). In 45 patients with Sjogren's syndrome, we examined the 2 types of IVD with respect to serologic associations. NIVD, unlike MIVD, was significantly associated with seroreactivity reflected by hyperglobulinemia (P = 0.01), rheumatoid factor (P = 0.002), antinuclear antibodies (P = 0.02), and antibodies to Ro (SS-A) (P = 0.00006), and with hypocomplementemia (P = 0.03). The differential association of the 2 types of IVD with serologic reactivity and hypocomplementemia suggests that there may be basic differences in the immunopathogenesis of these 2 forms of IVD in Sjogren's syndrome.Inflammatory vascular disease (IVD) is increasingly being recognized as a complication of Sjogren's syndrome (SS) (1,2). Two distinct types of IVD have been observed (2): neutrophilic IVD (NIVD) and mononuclear IVD (MIVD). We previously reported a Publication #570 of the O'Neill Research Laboratories,

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“…In rheumatoid arthritis (RA)' patients, seropositive for rheumatoid factor (RF+), the occurrence of 7S IgM is associated with disease severity and frequently with vasculitis, (11,12). In immunodiffusion studies using specific antiIgM antibodies reacting with 19S or 7S IgM the characteristics of 7S IgM appear identical to those of pentameric 19S IgM (4,13,14).…”

Section: Introductionmentioning

confidence: 99%

Monomeric (7S) IgM found in the serum of rheumatoid arthritis patients share idiotypes with pentameric (19S) monoclonal rheumatoid factors.

Bonagura¹,

Mendez²,

Agostino³

et al. 1987

J. Clin. Invest.

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IgM rheumatoid factor and low molecular weight IgM. An association with vasculitis

Cited by 116 publications

References 50 publications

In vitro induction of proinflammatory cytokine secretion by juvenile rheumatoid arthritis synovial fluid immune complexes

In vitro induction of proinflammatory cytokine secretion by juvenile rheumatoid arthritis synovial fluid immune complexes

Two types of inflammatory vascular disease in Sjögren's syndrome. Differential association with seroreactivity to rheumatoid factor and antibodies to Ro (SS‐A) and with hypocomplementemia

Monomeric (7S) IgM found in the serum of rheumatoid arthritis patients share idiotypes with pentameric (19S) monoclonal rheumatoid factors.

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