IgM paraproteins.

Long-term follow-up of IgM monoclonal gammopathy of undetermined significance

“…[9][10][11][12][13] Patients with IgM MGUS constituted only a small proportion of patients in these studies. In 1 study, 10 IgM monoclonal gammopathy was an incidental finding in 31% of 160 asymptomatic patients, but only 11 were classified as having benign disease (MGUS) after follow-up. In most of these patients, Waldenström macroglobulinemia or malignant lymphoma developed, and the authors emphasized the need for follow-up of more than 10 years.…”

“…Little effort has been made to determine the nature and frequency of adverse outcomes of MGUS of the IgM class, which has different clinical features and progresses to lymphoma or Waldenström macroglobulinemia rather than to multiple myeloma. [9][10][11][12][13] Among 242 patients with MGUS of the IgM type recognized at the Mayo Clinic from 1956 to 1978, a group of malignant lymphoid disorders developed in 40 (17%) patients an average of 4 years after recognition of the M protein. 9 These disorders included Waldenström macroglobulinemia in 22 patients, lymphoproliferative disorder in 9, lymphoma in 6, primary amyloidosis (AL) in 2, and chronic lymphocytic leukemia in 1.…”

Significance of immunoglobulin deposition in peripheral nerve in neuropathies associated with paraproteinaemia.

“…1). (Propp et al, 1975;Hobbs et al, 1975), and in the endoneurium and perineurium (Chazot et al, 1974(Chazot et al, , 1976 in patients with Waldenstrom's macroglobulinaemia and peripheral neuropathy. In addition, monoclonal IgG and IgA has been found in nerve biopsy samples of patients with myeloma and peripheral neuropathy (Chazot et al.…”

Characteristics and Prognosis of Patients with Immunoglobulin M Monoclonal Gammopathy

“…Hiroaki Tanaka, 1) Yukie Sakuma, 2) Hideki Ikeda, 3) Ryo Shimizu, 1) Yasumasa Sugita, 1) and Rie Iwai 4) Many patients with immunoglobulin M (IgM) monoclonal gammopathy remain asymptomatic and, consequently, untreated; however, few studies have evaluated the clinical course and prognosis of these patients. Using the screening procedures at our hospital, 74 patients with IgM monoclonal gammopathy were selected.…”

“…1,2 Most patients with IgM monoclonal gammopathy remain asymptomatic and, consequently, untreated 1,3,4 ; however, as such patients are relatively rare and have long clinical courses, there are fewer studies analyzing the clinical course and prognosis of patients with IgM monoclonal gammopathy. Furthermore, as monoclonal gammopathy is examined only when there are symptoms or clinical findings that raise suspicion of its presence, the number of patients with IgM monoclonal gammopathy who are undiagnosed because of the asymptomatic course of the disease remains unknown.…”