Characteristics and Prognosis of Patients with Immunoglobulin M Monoclonal Gammopathy

Tanaka, Hiroaki; Sakuma, Yukie; Ikeda, Hideki; Shimizu, Ryo; Sugita, Yoshiaki; Iwai, Rie

doi:10.3960/jslrt.17025

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Another study by Tanaka et al, reported that overall survival in patients with monoclonal gammopathy was significantly associated with four factors, including age, albumin level, hemoglobin level, and total protein. Patients with age less than 70 years old (p<0.01), albumin level >3.5g/dL (p<0.01), hemoglobin level >10 g/dL (p=0.03), and total protein <8.5g/dL ( p=0.03) were associated with better prognosis and higher overall survival [22] .…”

Section: Discussionmentioning

confidence: 98%

Hepatitis C Positive Patients in Relation to Polyclonal and Monoclonal Gammopathy: An Egyptian Experience

MOSTAFA¹,

FODA

2022

The Medical Journal of Cairo University

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Background: Gammapathies is one of long term complication of chronic HCV Infection B-cell lymphoproliferative diseases produced by a clonal proliferation of plasma cells producing a unique immunoglobulin are known as monoclonal gammopathies. Their clinical spectrum includes monoclonal gammopathy of undetermined significance (MGUS) and overt multiple myeloma. Aim of Study:The present study aimed to examine the prevalence, characteristics, and predictors of gammopathies in Egyptian patients with chronic HCV infection.Patients and Methods: This study conducted a prospective cohort study on patients with bilateral baggy lower eyelids who underwent traditional lower blepharoplasty with fat excision or fat-sparing technique using the orbital septal plication method. Results:The study was performed on 40 patients (20 patients per group). The right medial OGS showed a significant reduction in the fat-sparing and traditional groups ( p<0.001, each). However, the percentage of reduction was significantly higher in the fat-sparing group (35.8 ± 2.8 versus 14.6±3.4 in the traditional groups; p<0.001). Likewise, the left medial OGS showed a significant reduction in the fat-sparing and traditional groups (p<0.001, each). The percentage of reduction was significantly higher in the fat-sparing group (35.9 ±2.9 versus 14.7±3.3 in the traditional groups; p<0.001). Both left and right-sided central and lateral OGS showed a significant reduction in the fat-sparing and traditional groups ( p<0.001, each). However, the percentage of reduction was significantly higher in the fat-sparing group ( p<0.001, each). Conclusion:In conclusion, the prevalence of polyclonal gammopathy was higher in patients with chronic HCV compared with monoclonal, which is reported to be related to old age. Patients with gammopathy were associated with anemia, altered coagulation profile, high alfa-fetoprotein, low albumin level, and leukocytosis. Enlarged spleen, male gender, WBCS <5.000cc/mm 3 , and platelets below 120.000 are significant predictors of gammopathy in patients with chronic HCV.

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Section: Discussionmentioning

confidence: 98%

Hepatitis C Positive Patients in Relation to Polyclonal and Monoclonal Gammopathy: An Egyptian Experience

MOSTAFA¹,

FODA

2022

The Medical Journal of Cairo University

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“…Long-term follow-up is important, because IgM MGUS may progress to lymphoplasmacytic lymphoma or other B-cell lymphomas [3,31].…”

Section: Discussionmentioning

confidence: 99%

Unusual manifestation of monoclonal gammopathy of undetermined significance: a false serum creatinine elevation

Shimamura

Maeda

Ogawa³

et al. 2019

CEN Case Rep

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A 72-year-old Japanese man with diabetes mellitus and hypertension presented with an acutely elevated serum creatinine level, from 1.02 to 4.13 mg/dL over 2 months as measured by the enzymatic method by pure-auto S CRE-N ® . Renal biopsy could not identify the etiology of the elevating sCr. However, an elevated total protein level (8.2 g/dL) and lowering of the BUN and sCr ratio from 14.5 to 2.7 were found, and bone marrow biopsy showed less than 10% lymphoplasmacytic infiltration, compatible with monoclonal gammopathy of undetermined significance. The diagnosis of a false serum creatinine elevation due to monoclonal gammopathy of undetermined significance was confirmed with the serum cystatin C level at 1.05 mg/ dL and the creatinine level of 0.97 mg/dL using Shikarikid-S CRE ® method. Although cases of monoclonal gammopathy of undetermined significance with a false serum creatinine elevation as an initial presentation are rare, this condition should be considered in patients with paraproteinemia; measuring the renal function using cystatin C is important in such patients.

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Serum markers in the differential diagnosis of Waldenstrom macroglobulinemia and other IgM monoclonal gammopathies

Zou

Yang

Liao

et al. 2018

Clinical Laboratory Analysis

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Background IgM monoclonal gammopathy can be present in a broad spectrum of diseases. We evaluated the value of serum markers in the differential diagnosis of Waldenstrom macroglobulinemia (WM) and other types of IgM monoclonal gammopathies. Methods We included patients who were first admitted to hospital and identified as having IgM monoclonal gammopathy by serum immunofixation electrophoresis (sIFE). We evaluated basic clinical features, sIFE, diagnosis, and serum markers. Furthermore, we applied the receiver operating characteristic (ROC) curve to analyze the differential diagnosis value of serum markers for WM. Finally, we used logistic regression and ROC curve to analyze the differential diagnosis value of multimarker combinations to identify WM. Results IgM monoclonal gammopathy was most frequently found in patients with Waldenstrom macroglobulinemia, followed by monoclonal gammopathy of undetermined significance (MGUS), B‐cell non‐Hodgkin Lymphoma (B‐NHL), and multiple myeloma (MM). Serum markers showed significant differences among the four diseases. The diagnostic markers LDH, IgM, IgG, IgA, and serum light chain К had higher diagnostic efficiency. Among these markers, serum IgM provided the highest diagnostic efficiency. Additionally, the combined use of all five serum markers provided the most effective diagnosis. Conclusions The five serum markers, LDH, IgM, IgG, IgA, and К, each yielded a specific efficacy in differential diagnosis of WM. The single marker with the highest diagnostic efficiency was the serum IgM level. However, a combination of multiple serum markers was better than the use of a single marker in diagnosing WM. The combined use of all five serum markers provided the most effective diagnosis, with an AUC of .952 and sensitivity and specificity of 87.8% and 86.9%, respectively.

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Characteristics and Prognosis of Patients with Immunoglobulin M Monoclonal Gammopathy

Cited by 4 publications

References 21 publications

Hepatitis C Positive Patients in Relation to Polyclonal and Monoclonal Gammopathy: An Egyptian Experience

Hepatitis C Positive Patients in Relation to Polyclonal and Monoclonal Gammopathy: An Egyptian Experience

Unusual manifestation of monoclonal gammopathy of undetermined significance: a false serum creatinine elevation

Serum markers in the differential diagnosis of Waldenstrom macroglobulinemia and other IgM monoclonal gammopathies

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