IgM autoantibodies to 180- and 230- to 240-kd human epidermal proteins in pregnancy

Borradori, L.

doi:10.1001/archderm.131.1.43

Cited by 7 publications

(6 citation statements)

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“…A maternal response to paternal antigens 21 and an association with sex hormones have also been suggested 22 , 23 but not substantiated. In addition, some studies have demonstrated circulating anti‐BMZ IgM autoantibodies 24 –26 . However, unlike in PG, IMF and autoantibody screens are negative and there are no known HLA associations.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of 200 women with dermatoses of pregnancy correlating clinical findings with hormonal and immunopathological profiles

et al. 1999

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In 1994 we set up a specialist clinic for pregnancy dermatoses, both to improve the management of pregnant women with skin problems and to enhance our general understanding of the pregnancy dermatoses. This clinic has provided a large database of 200 women which has formed the basis for a prospective study over a 2-year period. In each case the dermatological diagnosis was clearly defined on clinical criteria, with additional help from histopathology and direct immunofluorescence of the skin where appropriate. We have included a number of patients who presented with relatively trivial diagnoses, as this reflects the referral patterns of our midwives, general practitioners and obstetricians within our hospital and local population. Our results show that all patients with specific dermatoses of pregnancy conformed well to the classification established by Holmes and Black in 1983. The role of the sex hormones [oestradiol, human chorionic gonadotrophin (hCG) and cortisol] in polymorphic eruption (PEP) and prurigo of pregnancy was studied in 125 cases and compared with 138 normal healthy pregnant controls. For pruritic folliculitis (PF), serum androgens were measured to establish if these were elevated. Nearly all patients were followed up postpartum, with respect to both maternal and fetal prognosis (some were unfortunately lost to follow-up). Many patients were primiparous (47%) and presented in their third trimester (49%). This study shows a surprisingly high prevalence of eczema during pregnancy. It is possible that earlier cases in the literature termed prurigo of pregnancy may in fact have been eczema, thus explaining the low incidence of prurigo in this study. Hormonal analysis showed a significant reduction in serum cortisol levels in patients with PEP compared with normal pregnant controls (P = 0.03), although hCG and oestradiol showed no differences. Serum androgens were not significantly elevated in patients with PF compared with controls. Birthweight (analysed by the individualized birthweight ratio) was significantly reduced in both the PF and pemphigoid gestationis groups. In the PEP and PF groups there was a male/female infant ratio of 2 : 1, not noted in previous studies. In all cases studied there were no adverse effects either on maternal or fetal outcome as a result of the pregnancy dermatosis. This study indicates that all patients fulfilled the criteria of the previous classification of the specific dermatoses of pregnancy, although we also now highlight the frequency of eczema in pregnancy and speculate as to possible causes. There were no cases of papular dermatitis of pregnancy. We feel that the specialist clinic is an important service which has improved the management of these women and identified areas for further research.

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Section: Discussionmentioning

confidence: 99%

A prospective study of 200 women with dermatoses of pregnancy correlating clinical findings with hormonal and immunopathological profiles

et al. 1999

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“…Moreover, the DIF was clearly positive with anti‐IgM antibodies. This has been described frequently in the literature and suggests a weak IgM autoreactivity of pregnancy against epidermal proteins 11 …”

Section: Discussionmentioning

confidence: 54%

“…Moreover, only IEM permits study of the immune deposit location on structural components such as the interkeratinocytic desmosomes and the DEJ. The more important immuno‐ultrastructural data, as well as the corresponding target antigens, have been included in Table 1 6–17 …”

Section: Discussionmentioning

confidence: 99%

Ultrastructural immunocytochemistry of autoimmune bullous diseases

et al. 2002

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Advanced immunopathological assays have been developed to elucidate the pathophysiology and provide more precise nosological definitions of the immunobullous diseases. Forty-seven patients suffering from autoimmune bullous diseases (intra- or subepidermal) were studied by immunoelectron microscopy (direct and indirect). Peroxidase staining was revealed by diaminobenzidine (determination of immune deposit location) in the majority of the cases of subepidermal bullous diseases, but in less than half of the cases of intraepidermal bullous diseases. Immunoelectron microscopy features contributed in verifying the diagnosis of rare entities such as cicatricial pemphigoid, paraneoplastic autoimmune bullous disease, linear IgA disease and epidermolysis bullosa acquisita.

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“… 19 Equivalent dilutions of patient and control sera were tested against keratinocyte extracts by immunoblotting (IB), as described in detail elsewhere 19 ,. 20 Extracts were subjected to sodium dodecyl sulphate–polyacrylamide gel electrophoresis, then transferred electrophoretically to nitrocellulose and stained by the peroxidase method. Sera were tested at a dilution of 1 : 10 in washing buffer.…”

Section: Methodsmentioning

confidence: 99%

Childhood bullous pemphigoid associated with IgA antibodies against BP180 or BP230 antigens

Arechalde

Braun

et al. 1999

British Journal of Dermatology

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Linear IgA bullous dermatosis (LABD) comprises a heterogeneous group of subepidermal blistering disorders characterized by in situ bound IgA antibodies in epidermal basement membrane. We report three children presenting clinical and immunopathological features characteristic of LABD. By immunoblotting, the three patients' sera contained IgA antibodies that reacted against the bullous pemphigoid (BP) antigen 180 and or BP230, molecular markers for BP. In addition, IgG antibodies directed against the ectodomain of BP180 were detected by an enzyme-linked immunosorbent assay using a eukaryotic recombinant form of BP180. Consistent with recent studies suggesting that the LABD antigen 1, the predominant autoantigen of LABD, is either a proteolytic product of BP180 or an isoform of the BP180 gene, our findings indicate that a subset of children with features of LABD have a distinct form of BP associated with an IgA response.

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IgM autoantibodies to 180- and 230- to 240-kd human epidermal proteins in pregnancy

Cited by 7 publications

References 0 publications

A prospective study of 200 women with dermatoses of pregnancy correlating clinical findings with hormonal and immunopathological profiles

A prospective study of 200 women with dermatoses of pregnancy correlating clinical findings with hormonal and immunopathological profiles

Ultrastructural immunocytochemistry of autoimmune bullous diseases

Childhood bullous pemphigoid associated with IgA antibodies against BP180 or BP230 antigens

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