Background The diagnosis of atopic dermatitis (AD) is made using evaluated clinical criteria. Management of AD

Linear IgA bullous dermatosis (LABD) comprises a heterogeneous group of subepidermal blistering disorders characterized by in situ bound IgA antibodies in epidermal basement membrane. We report three children presenting clinical and immunopathological features characteristic of LABD. By immunoblotting, the three patients' sera contained IgA antibodies that reacted against the bullous pemphigoid (BP) antigen 180 and or BP230, molecular markers for BP. In addition, IgG antibodies directed against the ectodomain of BP180 were detected by an enzyme-linked immunosorbent assay using a eukaryotic recombinant form of BP180. Consistent with recent studies suggesting that the LABD antigen 1, the predominant autoantigen of LABD, is either a proteolytic product of BP180 or an isoform of the BP180 gene, our findings indicate that a subset of children with features of LABD have a distinct form of BP associated with an IgA response.

8 Lucker GPH, Heremans AMC, Boegheim PJ et al. Oral treatment of ichthyosis by modulating endogenous retinoic acid: a new concept for the treatment of keratinization disorders. Br J Dermatol 1997; 136:71-5. 9 Dockx P, Decree J, Degreef H. Inhibition of the metabolism of endogenous retinoic acid as treatment for severe psoriasis: an open study with oral liarozole. Br J Dermatol 1995; 133:426-32. 10 Berth-Jones J, Todd G, Hutchinson PE et al. Treatment of psoriasis with oral liarozole: a dose-ranging study.

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