ighting antimicrobial resistance in ESKAPE pathogens

Trastoy, Rocío; Blasco, Lucía; Bou, Germán; Tomás, María

doi:10.5599/obp.15.9

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…Due to the high pressure exerted by antimicrobial resistance and the increasing prevalence of multiresistant bacteria, the development of new and beneficial treatments is required. Several treatments against multiresistant pathogens have been developed over time, including: new drugs, phage therapy (including derivates), antivirulence therapy, lysins, antibodies, probiotics, and immune stimulation [ 13 ]. The particular problem with antimicrobial treatment is the delivery method of the antimicrobial agents and avoiding the systemic uptake that increases the selection of resistant bacteria.…”

Section: Introductionmentioning

confidence: 99%

Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance

Carpa

Remizovschi

Culda

et al. 2022

Gels

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Antibiotic resistance has increased significantly in the recent years, and has become a global problem for human health and the environment. As a result, several technologies for the controlling of health-care associated infections have been developed over the years. Thus, the most recent findings in hydrogel fabrication, particularly antimicrobial hydrogels, could offer valuable solutions for these biomedical challenges. In this review, we discuss the most promising strategies in the development of antimicrobial hydrogels and the application of hydrogels in the treatment of microbial infections. The latest advances in the development of inherently and composite antimicrobial hydrogels will be discussed, as well as hydrogels as carriers of antimicrobials, with a focus on antibiotics, metal nanoparticles, antimicrobial peptides, and biological extracts. The emergence of CRISR-Cas9 technology for removing the antimicrobial resistance has led the necessity of new and performant carriers for delivery of the CRISPR-Cas9 system. Different delivery systems, such as composite hydrogels and many types of nanoparticles, attracted a great deal of attention and will be also discussed in this review.

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Section: Introductionmentioning

confidence: 99%

Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance

Carpa

Remizovschi

Culda

et al. 2022

Gels

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show abstract

“…Las infecciones causadas por este patógeno son habitualmente difíciles de tratar debido a la resistencia intrínseca a los antibióticos que se utilizan para su tratamiento [7]. Los antibióticos carbapenémicos son parte del arsenal terapéutico utilizado en el tratamiento de las infecciones causadas por ambos patógenos, pero el incremento progresivo de las infecciones por enterobacterias resistentes a cefalosporinas de tercera generación ha conllevado un incremento sustancial de su uso y ello, sumado a la rápida diseminación de los genes de resistencia entre distintos grupos bacterianos, ha favorecido la emergencia de resistencia a este grupo de antibióticos [8,9]. Generalmente, los factores de riesgo (FR) asociados a infecciones por microorganismos resistentes a un determinado grupo de antibióticos incluyen: características del huésped (comorbilidad), exposición previa a antibióticos, y realización de procedimientos invasivos [10].…”

Section: Introductionunclassified

A systematic review and expert’s analysis of risk factors of infections in adults due to carbapenem-resistant Pseudomonas aeruginosa or Acinetobacter baumannii in Spain

Ferrer¹,

Soriano²,

Cantón³

et al. 2021

Rev Esp Quimioter

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Objective. The aim of the study is to identify risk factors associated to infections caused by carbapenem-resistant Pseudomonas aeruginosa (CRPA) and carbapenem-resistant Acinetobacter baumannii (CRAB) in adult patients through a systematic literature review, classify them according to their importance and provide recommendations by experts in the Spanish context. Material and methods. We developed a systematic literature review to identify risk factors associated to CRPA or CRAB infections and they were evaluated and discussed by a multidisciplinary panel of experts. Results. There were included 29 studies for P. aeruginosa and 23 for A. baumannii out of 593 identified through systematic literature review. We identified 38 risk factors for P. aeruginosa and 36 for A. baumannii. After risk factor evaluation by the panel of experts, results for CRPA were: 11 important, 10 slightly important and 15 unimportant risk factors; and for CRAB were: 9 important, 5 slightly important and 19 unimportant risk factors. For both pathogens, previous use of antibiotics and hospitalization were important risk factors. Conclusion. We could identify the main risk factors associated to CRPA and CRAB through literature review. There is a need for developing additional studies with higher levels of evidence to identify sooner and better infected patients through associated risk factors.

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Natural Inhibitors of Quorum-Sensing Factors: a Novel Strategy to Control Pathogenic Bacteria

Peña-González

Muñoz-Cázares

Peña‐Rodríguez

2020

Rev. Bras. Farmacogn.

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ighting antimicrobial resistance in ESKAPE pathogens

Cited by 3 publications

References 36 publications

Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance

Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance

A systematic review and expert’s analysis of risk factors of infections in adults due to carbapenem-resistant Pseudomonas aeruginosa or Acinetobacter baumannii in Spain

Natural Inhibitors of Quorum-Sensing Factors: a Novel Strategy to Control Pathogenic Bacteria

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