IgG4-related disease and isolated thoracic aortic aneurysm

A case of immunoglobulin G4‐related aortic diseases

“…Aneurysmal changes, as shown in our case, can also occur. Nuñez Fernández and colleagues described a case of aneurysmal dilatation of the ascending aorta . Diagnosis of IgG4‐related aneurysmal changes is made by immunohistochemistry, with greater than 50% of IgG4‐positive cells and an IgG4/IgG cell ratio greater than 0.4.…”

“…IgG4‐related diseases are newly recognized systemic disorders, and they can affect a variety of different organs. IgG4‐related inflammatory changes can also cause different morphological changes in the aorta .…”

Immunoglobulin G4-Related Cardiovascular Diseases

“…[32][33][34][35][36][37][38][39] Lindsay and colleagues presented a case with periaortitis. 32) An abdominal CT scan revealed periaortic soft tissue surrounding the abdominal aorta from below the level of the renal arteries.…”

“…Nuñez Fernández and colleagues described a case of aneurysmal dilatation of the ascending aorta. 36) Diagnosis of IgG4-related aneurysmal change is by immunohistochemistry, with greater than 50% IgG4-positive cells and an IgG4/ IgG cell ratio greater than 0.4. Colombier and colleagues reported a similar case with an asymptomatic ascending aortic aneurysm and thickening of the aortic wall.…”

Non-infectious aortitis of the ascending aorta: a histological and clinical correlation of 71 cases including overlap with medial degeneration and atheroma—a challenge for the pathologist

“…Armed with this knowledge, patients with the diffuse pattern of inflammation histologically may require more exhaustive investigation to detect systemic disease or may be more suitable candidates to receive systemic anti-inflammatory treatment. Indeed, and although not evaluated for in our study, there is increasing recognition that a subset of diffuse lymphoplasmacytic aortitis is within the spectrum of so-called IgG4-related sclerosing disease, with important clinical and therapeutic ramifications 2 22…”