Immunoglobulin G4-Related Cardiovascular Diseases

Misawa, Yoshio

doi:10.5761/atcs.ra.17-00093

Cited by 13 publications

(19 citation statements)

References 47 publications

(60 reference statements)

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“…3 ). All patients with IgG4-related constrictive pericarditis were treated with pericardiectomy, and in some cases, this was followed by corticosteroid therapy [ 29 ].…”

Section: Pericardial Lesionsmentioning

confidence: 99%

Multimodalities Imaging of Immunoglobulin 4-related Cardiovascular Disorders

Fathala¹

2019

CCR

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Immunoglobulin 4 (IgG4)-related systemic disease (IgG4-RSD) is a systemic inflammatory disease characterized by elevation of serum IgG4. IgG4-RSD can affect any organ in the body, and the list of organs associated with this condition is growing steadily. IgG4-related cardiovascular disease affects the coronary arteries, heart valves, myocardium, pericardium, aorta, pulmonary and peripheral vessels. Echocardiography is the most commonly used non-invasive imaging method. Computed tomography angiography (CTA) can assess aortitis, periarteritis and coronary aneurysms. Coronary CTA is fast, offers high spatial resolution and a wide coverage field of view. Cardiac magnetic resonance imaging (CMR) offers a comprehensive evaluation of the cardiovascular system including cardiac function, extent of myocardial fibrosis, characterise cardiac masses with different pulse sequences and guide to further treatment. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) can provide important information about the extent of disease, the presence of active inflammation and the optimum biopsy site. In general, the role of diagnostic imaging includes establishing the diagnosis, detecting complications, guiding biopsy and documenting response to therapy.

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“…3 ). All patients with IgG4-related constrictive pericarditis were treated with pericardiectomy, and in some cases, this was followed by corticosteroid therapy [ 29 ].…”

Section: Pericardial Lesionsmentioning

confidence: 99%

Multimodalities Imaging of Immunoglobulin 4-related Cardiovascular Disorders

Fathala¹

2019

CCR

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“…1,2 IgG4RD presents with a variety of symptoms according to the organ affected and may be accompanied by serious complications such as organ dysfunction associated with IgG4-positive cell proliferation. 4 We report the case of a 50-year-old man with IgG4RD involving abdominal and extra-abdominal organs. The diagnosis was not considered for about 10 years after the initial presentation until an excisional biopsy of the right mandibular gland was positive for IgG4.…”

Section: Introductionmentioning

confidence: 98%

“…IgG4-related disease (IgG4RD) was originally discovered in patients with autoimmune pancreatitis accompanied by elevated serum IgG4 levels 1,2 and has subsequently been described in almost every organ system. [1][2][3][4] IgG4related cardiovascular disease can affect the coronary arteries, heart valves, myocardium, pericardium, aorta, and peripheral vasculature. 4 IgG4RD is characterized by diffuse lymphoplasmacytic infiltrates and the presence of abundant IgG4-positive plasma cells within extensive fibrosis, frequently associated with tumorous swelling and elevated serum IgG4 concentrations.…”

Section: Introductionmentioning

confidence: 99%

Multisystem IgG4-related disease involving the abdomen and coronary arteries and causing chronic abdominal pain

Lee

Glockner

2021

Acta Radiologica Open

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IgG4-related disease was originally discovered in patients with autoimmune pancreatitis accompanied by elevated serum IgG4 levels and has subsequently been described in almost every organ system. IgG4-related disease presents with a variety of symptoms according to the organ affected and may be accompanied by serious complications such as organ dysfunction associated with IgG4-positive cell proliferation. We report a case of IgG4-related abdominal disease in a patient who also had involvement of the coronary artery.

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“…Despite its importance for postoperative disease management, a definitive diagnosis of IgG4-related disease is not easy to obtain preoperatively. 3 ) IgG4-related inflammation can induce morphological changes in the aorta. For example, Lindsay et al 4 ) presented a case of periaortitis with periaortic soft tissue surrounding the abdominal aorta.…”

mentioning

confidence: 99%