IgG4 Antibodies in Hay Fever Patients

Chernokhvostova, E V; Kotova, T S; German, G P; Atovmian, O I

doi:10.1159/000235180

Cited by 6 publications

(1 citation statement)

References 13 publications

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“…Antibodies to carbohydrate antigens and bacterial polysaccharides arc usually IgG2 [20,21], while antibodies to ovalbumin, gliadin, cow's milk and other foods are mostly of the IgG4 subclass [7,22,23]. Moreover, it has been proposed that elevated specific IgG4 antibodies re flect prolonged exposure to the antigen occurring in the intestinal tract [4,9,23,24], This an important statement because of the fact that Aspergillus species frequently con taminate foods [25]; therefore one may speculate that the intestinal route of sensitization may be responsible for the high level of IgG4 antibodies in this group of patients as well as the high IgG4 antibodies levels (although less marked) in the atopic and normal groups.…”

Section: Discussionmentioning

confidence: 99%

IgG Subclass Response to <i>Aspergillus fumigatus</i>

Igea¹,

Cuevas

Marcos³

et al. 1993

Int Arch Allergy Immunol

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The exact clinical meaning of the IgG subclass antibodies remains obscure. In order to contribute to the study of the IgG subclass response, specific IgG_totaland IgG subclass antibodies to Aspergillus fumigatus (Af) were determined by enzyme-linked immunosorbent assay (ELISA) in three groups of patients: 30 asthmatics due to an IgG-mediated hypersensitivity to Af, 30 atopic and 30 nonatopic controls. The results demonstrated that Af-specific IgG_total, IgG2 and IgG4 antibodies are increased in Af-sensitive patients, although detectable levels of each specific IgG subclass could be found in all the three groups. No differences between atopic and non-atopic controls could be demonstrated.

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Section: Discussionmentioning

confidence: 99%

IgG Subclass Response to <i>Aspergillus fumigatus</i>

Igea¹,

Cuevas

Marcos³

et al. 1993

Int Arch Allergy Immunol

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Differences in titres of IgE, IgG4 and other IgG subclass anti‐ Der p 2 antibodies in allergic and non‐allergic patients measured with recombinant allergen

Tame

Sakiyama

Kobayashi

et al. 1996

Clin Experimental Allergy

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Humoral and Cellular Immunity to Candida albicans in Patients with Bronchial Asthma.

et al. 1992

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Delayed cutaneous reactivity to Candida albicans (C. albicans) and PPD (purified protein derivative) was examined in 52 patients with bronchial asthma in relation to the production of specific IgG4 antibodies against the antigen. 1. The frequency of a positive, immediate skin reaction to C. albicans was similar among the five age groups, ranging from 60.0% to 66.7%. 2. The incidence of a positive delayed skin reaction to C. albicans was lower in patients between the ages of 10 and 30 and tended to decrease with aging in the patients over the age of 51. 3. A delayed skin reaction to PPD was positive in patients between 31 and 50 with a higher incidence; this incidence decreased in patients over age 51. 4. The level of C. albicans-specific IgG4 antibodies was significantly higher (26.7 u/ml) in patients with a negative delayed skin reaction to the antigen than in those with a positive reaction (5.9u/ml) (p <0.001). There was no correlation between delayed skin reaction to PPD and production of specific IgG4 antibodies. (Internal Medicine 31: 766-769, 1992)

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IgG4 Antibodies in Hay Fever Patients

Cited by 6 publications

References 13 publications

IgG Subclass Response to <i>Aspergillus fumigatus</i>

IgG Subclass Response to <i>Aspergillus fumigatus</i>

Differences in titres of IgE, IgG4 and other IgG subclass anti‐ Der p 2 antibodies in allergic and non‐allergic patients measured with recombinant allergen

Humoral and Cellular Immunity to Candida albicans in Patients with Bronchial Asthma.

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