IgG1, IgG2 and IgM responses to two Haemophilus influenzae type b conjugate vaccines in young infants

Protective immunogenicity of Haemophilus influenzae type b polysaccharide‐tetanus protein conjugate vaccine in children who failed to respond to prior invasive H. influenzae type b disease

“…Former studies showed that other PRP conjugate vaccines (PRP-OMPC and HBOC) induce predominantly IgG, PRP antibody responses (11,12). The response pattern observed in the present study is consistent with those reports and with the concept that the protein-bound PRP antigen elicits a T-cell mediated response which in turn induces preferentially an IgG, antibody production.…”

Current status of meningococcal group B vaccine candidates: capsular or noncapsular?

“…This process generally transforms the antigen from a thymus-independent to a thymus-dependent one, resulting in a stronger response than to the polysaccharide alone. It also gives rise to IgG antibodies and memory cells, as has been demonstrated for the meningococcal group A and C capsular polysaccharides (41), H. influenzae type b (12), pneumococcus (161,215), or the group B streptococcus (119,159).…”

Characteristics of Immune Responses to Native and Protein Conjugated Pneumococcal Polysaccharide Type 14

“…37]. It has been shown that OMPC has mitogenic features for lymphocytes [38] and causes T-cell independent macrophage activation and proliferation [37], Increase of macrophages in the spleen of mice is found after immunization with PRP-OMPC and not with PRP-CRM,97 The activated macrophages would then release cytokines like IL-1, which enhance the immune response of B cells [37]. It has been shown that for a normal TI-2 response IL-I is necessary [26,39,40].…”