Molecular dynamics simulations aimed at analysis of the rotational reorientation of tryptophan and 3-methylindole in water have been performed. The dependence of the rotational relaxation time of tryptophan on several simulation and model parameters has been evaluated. The considerable sensitivity found for particular parameters illustrates the necessity of a detailed analysis before jumping to conclusions regarding the validity of a molecular model and force field based on comparing simulation with experimental data. The best agreement with experimental data is obtained when using the extended simple-point-charge ͑SPC/E͒ model for water together with a reaction-field correction for the long-range electrostatic interactions.

PRP-T conjugate vaccine is able to elicit a protective immune response in children who have low or unmeasurable PRP antibody levels after a systemic Hib infection.

Four different types of chronic granulomatous disease (CGD) were analysed with the monoclonal antibody, 7D5, directed against the small 23 kD subunit of cytochrome b558 using a flow cytometric fluorescence analytical method. 7D5 immunofluorescent surface staining of granulocytes was absent in 12 patients with X‐linked cytochrome b558 deficiency, in 2 patients with variant X‐linked CGD with residual (X‐forming activity and in 2 patients with autosomal recessive cytochrome b558 deficiency. The mothers of the patients with the X‐linked form of CGD had 2 cell populations, one 7D5 negative or weakly positive and one 7D5 positive. The granulocytes of both parents of one patient with autosomal recessive cytochrome b558 deficiency had slightly reduced fluorescence intensity comparable to their reduced cytochrome b558 content. Three CGD patients with normal cytochrome b558 and their parents had granulocytes normally stained with antibody 7D5. 7D5 antibody enables rapid detection and classification of CGD patients with cytochrome b558 deficiency as well as rapid identification of heterozygous carriers.

Twenty years after "the Confucian among philosophers, the philosopher among Confucians" 1 passed away in 1995, Jason Clower presents a selection of English translations of texts by Mou Zongsan (1909-1995). "If twentieth-century China produced a philosopher of the first rank," Clower opens his introduction, "it was Mou Zongsan" (p. 1). On the one hand, there can be no doubt about Mou's deeply ingrained Confucianism, and his work bespeaks his familiarity with much of the philosophical heritage of both China and the occidentespecially its Ango-American, but also Graeco-Roman and German compartments. However, people like Yu Yingshi 余英時, Lin Anwu 林安梧, 2 but also mainlandbased scholars like Jiang Qing 蔣慶 have criticised Mou for exiling Confucianism into the ivory tower of philosophical speculation, largely disregarding its societal and institutional aspects and their potential relevance for present day China. Likewise, Mou's exceptional status as a philosopher, suggested by Clower and claimed by many of his students and convinced readers, remains controversial. 3 What is beyond contention, however, is that Mou was not only an erudite and polymath, but also an extremely prolific writer. His studies penetrate the remotest confines of Chinese intellectual history and his collected works comprise several thousand pages in 32 volumes. 4 In the course of the last two decades, Mou 1 This is how Cai Renhou, one of Mou's most prominent students and professor emeritus at Tunghai University in Taichung, has characterised Mou in his obituary (Lehmann 1998: 197). 2 For a short overview in English see Makeham 2008: 176-180. 3 Lee Ming-Huei, another of Mou's students, at one point praises his teacher's "philosophical genius" (Lee 2001: 65). This enthusiasm is not restricted to Mou's immediate students: In a recent study based on her PhD thesis, N. Serina Chan at least twice asserts Mou's theoretical "genius" (Chan 2011: 116, 186). On the other extreme of the scale, there are people like Stephan Schmidt who with respect to Mou's claim that his moral metaphysics has sublated (aufgehoben) "the vastly different dualisms" discussed by Mou states that "this is unpersuasive to the point of caricature" (Schmidt 2011: 272).