IGFBP‐1 levels in adult women born small for gestational age suggest insulin resistance in spite of normal BMI

Abstract

Abstract. Kistner A, Jacobson SH, Celsi G, Vanpee M, Brismar K (Karolinska Hospital and Karolinska Institutet, Stockholm, Sweden). IGFBP-1 levels in adult women born small for gestational age suggest insulin resistance in spite of normal BMI. J Intern Med 2004; 255: 82-88.Objective. Impaired fetal development may contribute to decreased insulin sensitivity. This study was designed to characterize serum markers of insulin resistance in adults born small for date or born prematurely. Study design. Fifty subjects, all women, were evaluated at a mean age ± SD of 26 ± 2 years (range: 23-30 years). They were allocated to three groups: (i) born fullterm with birth weight <2600 g (n ¼ 18) (small for gestational age, SGA), (ii) born before gestational week 32 (n ¼ 15) (ex-preterm), and (iii) controls, born fullterm with appropriate birth weight (n ¼ 17). Anthropometric data as well as fasting serum samples of plasma B-glucose, serum lipids, insulin, insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-1 (IGFBP-1) levels were determined. Results. In the SGA group final height was lower and they weighed less compared with the controls. Fasting insulin and glucose levels did not differ amongst the groups. Triglycerides were lower in the SGA group and in the ex-preterm group compared with the controls (P < 0.05). The SGA group showed lower IGFBP-1 levels compared with the controls median 17 (range 3-121) vs. 26 (7-67) lg L )1 ; P < 0.05]. The IGF-I levels in the SGA, ex-preterm and control groups were 212 ± 58, 259 ± 37 and 216 ± 32 lg L )1 , respectively, corresponding to a mean SD score of )0.8 ± 1.0, 0.1 ± 0.6 and )0.6 ± 0.6. Conclusion. As IGFBP-1 is a marker of insulin sensitivity, the low levels observed in adult women with normal BMI, born small for date, suggest relative insulin resistance in spite of normal BMI.

Effects of prenatal micronutrient and early food supplementation on metabolic status of the offspring at 4.5 years of age. The MINIMat randomized trial in rural Bangladesh

“…As IGFBP-1 is a marker of insulin sensitivity, 55 this suggests a potentially reduced future risk of CVD. In a Swedish study, adult women born small for gestational age were shorter and had lower IGFBP-1 levels compared with full-term controls, suggesting reduced growth together with relative insulin resistance 56 . In our studied children, however, lower IGF-1 and stunted growth were accompanied by higher IGFBP-1.…”

Body shape throughout life and correlations with IGFs and GH

“…One study associated birth weight positively with IGFBP-1 levels in older age (Kajantie et al 2003), which is in line with our findings. Similarly, in the only other study (Kistner et al 2004) among 50 young adult women, IGFBP-1 levels were lower in adult women born full-term but small for gestational age -yet, a correlation with birth weight was not reported.…”

Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age

“…Kamoda T et al reported that the levels of serum IGFBP-1 were similar in short children born SGA and AGA [35]. Kistner A et al investigated the serum markers of insulin resistance in adults born SGA and reported that lower IGFBP-1 and triglyceride levels were observed in the SGA group compared to the AGA group despite with normal BMI [36]. In our study, there were no marked differences in IGFBP-1 and triglyceride levels between SGA children with height and BMI catch-up growth and their age-matched controls.…”