IgE Serum Levels in Psoriasis

Negosanti, M; Fanti, P. A.; Gasponi, A; Orlandi, Giovanna Mariah; Liverani, L; Tosti, Antonella

doi:10.1159/000250218

Cited by 8 publications

(6 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…in multiple sclerosis, Crohns's disease, arthritis, and also psoriasis (Louten et al, 2009). Interestingly, increased IgE levels have been reported in some patients suffering from psoriasis (Negosanti et al, 1981) and our data may explain these previous observations. The fact that not all patients develop increased IgE may depend on the genetic background as well (Wilsmann-Theis et al, 2008).…”

Section: Discussionsupporting

confidence: 75%

Interleukin-17A Promotes IgE Production in Human B Cells

Milovanović

Drozdenko

Weise

et al. 2010

Journal of Investigative Dermatology

103

View full text Add to dashboard Cite

Recently the Th1/Th2 concept has been revised and Th17 cells have been implicated in allergy. Despite clear correlative evidence, the cellular and molecular basis for the connection between increased IL-17A and IgE in allergy has not been elucidated. Here we show using flow cytometry that allergic patients have higher numbers of IL-17A+ cells compared to nonallergic donors. The selective removal of IL-17A+ cells from peripheral blood mononuclear cells of allergic donors after an IL-17A secretion assay reduces IgE levels, whereas re-addition of recombinant IL-17A restores it, as measured by ELISA, showing their important functional implication for IgE production. In addition, IL-17A directly promotes the differentiation of IgE-secreting cells and IgE production upon anti-CD40/IL-4 costimulation, as shown by enzyme-linked immunospot technique and ELISA. IL-17A triggers rapid degradation of IκBα and subsequent translocation of NF-κB into the B-cell nucleus, followed by transcription of epsilon germ-line, activation-induced cytidine deaminase, and IFN regulatory factor 4, as analyzed by flow cytometry, western blot, and quantitative real-time RT-PCR, respectively. Our study shows that IL-17A+ cells promote IgE production and that IL-17A exerts its pro-allergic effect directly at the level of B cells. Therefore, IL-17A might be a target for the treatment of IgE-dependent diseases, including atopic dermatitis.

show abstract

Section: Discussionsupporting

confidence: 75%

Interleukin-17A Promotes IgE Production in Human B Cells

Milovanović

Drozdenko

Weise

et al. 2010

Journal of Investigative Dermatology

103

View full text Add to dashboard Cite

show abstract

“…Within the last years, some issues concerning the existence of various antibody classes in the case of patients with psoriasis including IgE antibodies, responsible for atopic reactions have been already discussed [7][8][9][10][11]. In previous studies, serum levels of total IgE were significantly higher in psoriasis patients than in controls (42% vs. 10%; p < 0.05) [12].…”

Section: Discussionmentioning

confidence: 99%

Analysis of selected allergic reactions among psoriatic patients

Weryńska-Kalemba

Filipowska-Grońska

Kalemba

et al. 2016

pdia

View full text Add to dashboard Cite

Introduction Psoriasis is a chronic and recurrent inflammatory skin disease. The aetiology is still unknown in spite of numerous scientific researches. There is very little evidence which does not provide enough knowledge about allergic reactions in psoriatic patients. Based on the fact that the epidermal barrier damage allows different allergen types to penetrate into deep layers of epidermis and skin, we can assume that it may lead to immunological reactions. Aim To investigate the allergic reaction indicators and hypersensitivity assessment about contact, inhalant and food allergens. The results were analysed with regard to clinical disease indicators and progression stage of dermal lesions. Material and methods Eighty patients with psoriasis were examined. The concentration of total IgE antibodies and allergen specific IgE antibodies (asIgE) were analysed. Standard epidermal tests and atopy patch tests were performed. All the patients were estimated for their dermatological condition based on the PASI scale. The control group consisted of 50 patients without psoriasis and allergic history. Results Significantly higher concentration of total E immunoglobulin has been stated in the patients with psoriasis. Higher concentrations of specific allergic IgE antibodies were more often observed in the examined group but the most frequently observed values were present in 1–3 class. The most common airborne allergens were birch, artemisia, timothy and rye pollens. There have not been any significant statistical differences in the case of positive epidermal test results. Conclusions There is slightly expressed hypersensitivity in psoriatic patients. This hypersensitivity degree correlates with the intensification of symptoms.

show abstract

“…Previous studies have found increased total levels of IgE together with increased sensibilization for specific inhalation allergens and even increased prevalence of atopic diseases. [6-10]…”

Section: Introductionmentioning

confidence: 99%