IgE-Mediated Hypersensitivity and Contact Sensitivity to Multiple Environmental Allergens in Atopic Dermatitis

Identification of allergens by IgE‐specific testing improves outcomes in atopic dermatitis

“…12 Our study shows a median IgE concentration of 638.3 IU/ml, a number also significantly elevated in relation to the average individual. 12 Our study shows a median IgE concentration of 638.3 IU/ml, a number also significantly elevated in relation to the average individual.…”

“…IgEQAA may also be able to detect a patient's sensitiv- A study investigating the role of Candida albicans in atopy found that patients with AD were more likely to have a positive immune response to Candida albicans mannan than did controls; also, a significant correlation was shown between the severity of the disease and the patients' IgEQAA class. 12 As the American house dust mite, Dermatophagoides farinae is an allergen that most Americans are regularly exposed to. In their study, 12 patients with AD were cat owners.…”

Seasonal atopic dermatitis in dogs sensitive to a major allergen of Japanese cedar (Cryptomeria japonica) pollen

“…This suggests that additional factor(s) other than increased IgE antibody concentrations against the allergen is required to cause clinical atopic dermatitis in dogs. In humans with atopic dermatitis associated with CJ pollinosis, a report indicated a correlation between in vitro IgE testing and patch testing against CJ pollen allergen, suggesting that both type I hypersensitivity and type IV hypersensitivity could be involved in the development of atopic dermatitis 19 . A similar pathogenesis may be concerned in the development of atopic dermatitis in dogs sensitive to CJ pollen.…”

Semi‐purification of the immunoglobulin E‐sweat antigen acting on mast cells and basophils in atopic dermatitis

“…The basophil‐histamine release test showed high sensitivity (77.0%) and specificity (91.3%) for patients with AD and healthy controls. Many patients with AD are associated with high serum IgE levels and positive reactions in the skin prick test to various environmental and/or food antigens (18, 19). House dust mite is one of the commonest antigens to which many patients with AD are sensitive (20).…”

“…House dust mite is one of the commonest antigens to which many patients with AD are sensitive (20). However, many healthy individuals also show positive reactions to this antigen (42%) (19). On the contrary, the incident of sensitization of patients with AD against the other allergens, such as foods, pollens, and molds, is not higher than 70% (19).…”