IgE antibodies in relation to prevalence and multimorbidity of eczema, asthma, and rhinitis from birth to adolescence

Ballardini, Natalia; Bergström, Anna; Wahlgren, C F; Hage, Marianne van; Hallner, Eva; Kull, Inger; Melén, Erik; Antó, Josep M.; Bousquet, Jean; Wickman, Magnus

doi:10.1111/all.12798

Cited by 80 publications

(103 citation statements)

References 38 publications

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“…Atopy, atopic asthma and allergic diseases such as allergic rhinitis are common in Puerto Rican and Swedish children (11, 28). Moreover, allergic rhinitis is a frequent co-morbidity of atopic asthma (14, 29) and thus yet-to-be identified preventive measures against atopy and allergic rhinitis is likely to further impact the prevention of childhood asthma.…”

Section: Discussionmentioning

confidence: 99%

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Combined effects of multiple risk factors on asthma in school-aged children

Szentpetery

Gruzieva

Forno

et al. 2017

Respiratory Medicine

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Background Little is known about synergistic effects of several risk factors on asthma. We developed a risk score in Puerto Rican children, and then used this score to estimate the combined effects of multiple risk factors on asthma at school age in Puerto Rican and Swedish children. Methods Case-control study in 609 Puerto Rican children (aged 6–14 years) and longitudinal birth cohort study of 2,290 Swedish children followed up to age 12 years (The Children, Allergy, Milieu, Stockholm, Epidemiological Survey [BAMSE] Study). In both cohorts, there was data on parental asthma, sex, obesity, allergic rhinitis, and early-life second-hand smoke (SHS); data on diet and (in children ≥9 years) lifetime exposure to gun violence were also available in the Puerto Rico study. Asthma was defined as physician-diagnosed asthma and ≥1 episode of wheeze in the previous year. Results In a multivariable analysis in Puerto Rican children, male sex, parental asthma, allergic rhinitis, early-life SHS, an unhealthy diet and (in children ≥9 years) gun violence were each significantly associated with asthma. We next created a risk score using these variables (range, 0 to 5–6 in Puerto Rico and 0 to 4 in BAMSE). Compared with Puerto Rican children without any risk factors (i.e. a score of 0), Puerto Rican children with 2, 3, and at least 4 risk factors had 3.6 times (95% CI=1.4–9.2), 10.4 times (95% CI=4.0–27.0), and 21.6 times (95% CI=7.2–64.9) significantly higher odds of asthma, respectively. In BAMSE, the presence of 2, 3, and at least 4 risk factors was significantly associated with 4.1 times (95% CI=2.3–7.4), 6.3 times (95% CI=3.0–13.3), and 17.2 times (95% CI=4.1–73.2) increased odds of asthma at age 12 years. Conclusions Our findings emphasize the multifactorial etiology of asthma, and suggest that concurrent eradication or reduction of several modifiable risk factors may better prevent or reduce the burden of childhood asthma.

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Section: Discussionmentioning

confidence: 99%

“…Subject recruitment and baseline characteristics of participants in the BAMSE Swedish birth cohort study have been previously described (10, 11). In brief, between 1994 and 1996, 4,089 newborn infants were recruited and questionnaire data were obtained.…”

Section: Methodsmentioning

confidence: 99%

Combined effects of multiple risk factors on asthma in school-aged children

Szentpetery

Gruzieva

Forno

et al. 2017

Respiratory Medicine

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“…Despite the recent focus on the clustering of aeroallergens that have similar sensitization effects in children [1,5], the association of allergic disease severity with polysensitization remains relatively understudied [16,34,38]. Polysensitization is significantly associated with a poor quality of life in patients with allergic rhinitis [17] and intermittent asthma [19], and with higher asthmatic symptom scores for dyspnea, wheezing, and cough [13].…”

Section: Discussionmentioning

confidence: 99%

“…There is a strong association between IgE sensitization and allergic diseases [1,5], but the attributable risk is only 30-50% [2,6,7]. The presence, severity, and number of factors associated with IgE sensitization are important indicators for diagnosing [8,9,10] and predicting the progression of allergic diseases [11].…”

Section: Introductionmentioning

confidence: 99%

Association of Polysensitization, Allergic Multimorbidity, and Allergy Severity: A Cross-Sectional Study of School Children

Ha¹,

Baek²,

Lee³

et al. 2016

Int Arch Allergy Immunol

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Background: Aeroallergen sensitization is related to the coexistence of allergic diseases, but the nature of this relationship is poorly understood. The aim of this study was to clarify the relationship of polysensitization with allergic multimorbidities and the severity of allergic diseases. Methods: This study is a cross-sectional analysis of 3,368 Korean children aged 6-7 years-old. We defined IgE-mediated allergic diseases based on structured questionnaires, and classified the sensitivity to 18 aeroallergens by logistic regression and the Ward hierarchical clustering method. The relationship of polysensitization (positive IgE responses against 2 or more aeroallergens classes) with allergic multimorbidities (coexistence of 2 or more of the following allergic diseases: asthma, rhinitis, eczema, and conjunctivitis) and severity of allergic diseases was determined by ordinal logistic regression analysis. Results: The rate of polysensitization was 13.6% (n = 458, 95% CI 12.4-14.8) and that of allergic multimorbidity was 23.5% (n = 790, 95% CI 22.0-24.9). Children sensitized to more aeroallergens tended to have more allergic diseases (rho = 0.248, p < 0.001), although the agreement between polysensitization and multimorbidity was poor (kappa = 0.11, p < 0.001). The number allergen classes to which a child was sensitized increased the risk of wheezing attacks (1 allergen: adjusted odds ratio [aOR] 2.22, 4 or more allergens: aOR 9.39), absence from school (1 allergen: aOR 1.96, 3 allergens: aOR 2.08), and severity of nasal symptoms (1 allergen: aOR 1.61, 4 or more allergens: aOR 4.38). Conclusion: Polysensitization was weakly related to multimorbidity. However, the number of allergens to which a child is sensitized is related to the severity of IgE-mediated symptoms.

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“…Similarly, the 14-year follow-up analysis of an Australian community-based birth cohort showed that the proportion of asthma associated with atopy was 52% overall (9). The results of a recent cohort study, which followed a large group of newborns over various periods, indicated that the prevalence of asthma from 4 to 16 years is markedly higher among ever-allergic sensitized children compared to never-sensitized ones (10). At a population level, a recently published longitudinal study that prospectively collected data over the first four decades of life showed that the occurrence of asthma before the age of 13 years was more strongly associated with atopy and greater airflow obstruction than later onset asthma (11).…”

Section: Introductionmentioning

confidence: 99%