How Much Asthma Is Atopic in Children?

Comberiati, Pasquale; Cicco, Maria Di; D’Elios, Sofia; Peroni, Diego

doi:10.3389/fped.2017.00122

Cited by 38 publications

(30 citation statements)

References 37 publications

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“…Asthma is chronic airway inflammation characterized by different endotypes, and a wide variety of environmental stimulators can cause this disease . The most frequent endotype of asthma is allergic (or atopic) asthma . Allergic asthma, a type of T helper type 2 (Th2) ‐associated asthma, is induced by Th2 responses and allergen‐specific immunoglobulin E (IgE) .…”

Section: Introductionmentioning

confidence: 99%

“…1 The most frequent endotype of asthma is allergic (or atopic) asthma. 2 Allergic asthma, a type of T helper type 2 (Th2) -associated asthma, is induced by Th2 responses and allergen-specific immunoglobulin E (IgE). 3 The production of cytokines, including interleukin-4 (IL-4), IL-5, and IL-13, by Th2 cells produces importantly critical effects on asthmatic responses.…”

Section: Introductionmentioning

confidence: 99%

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Jagged1‐expressing adenovirus‐infected dendritic cells induce expansion of Foxp3⁺ regulatory T cells and alleviate T helper type 2‐mediated allergic asthma in mice

et al. 2018

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Summary Dendritic cells (DCs) are professional antigen‐presenting cells that play a key role in directing T‐cell responses. Regulatory T (Treg) cells possess an immunosuppressive ability to inhibit effector T‐cell responses, and Notch ligand Jagged1 (Jag1) is implicated in Treg cell differentiation. In this study, we evaluated whether bone marrow‐derived DCs genetically engineered to express Jag1 (Jag1‐DCs) would affect the maturation and function of DCs in vitro and further investigated the immunoregulatory ability of Jag1‐DCs to manipulate T helper type 2 (Th2) ‐mediated allergic asthma in mice. We produced Jag1‐DCs by adenoviral transduction. Overexpression of Jag1 by ovalbumin (OVA) ‐stimulated Jag1‐DCs exhibited increased expression of programmed cell death ligand 1 (PD‐L1) and OX40L molecules. Subsequently, co‐culture of these OVA‐pulsed Jag1‐DCs with allogeneic or syngeneic CD4+ T cells promoted the generation of Foxp3+ Treg cells, and blocking PD‐L1 using specific antibodies partially reduced Treg cell expansion. Furthermore, adoptive transfer of OVA‐pulsed Jag1‐DCs to mice with OVA‐induced asthma reduced allergen‐specific immunoglobulin E production, airway hyperresponsiveness, airway inflammation, and secretion of Th2‐type cytokines (interleukin‐4, interleukin‐5, and interleukin‐13). Notably, an increased number of Foxp3+ Treg cells associated with enhanced levels of transforming growth factor‐β production was observed in Jag1‐DC‐treated mice. These data indicate that transgenic expression of Jag1 by DCs promotes induction of Foxp3+ Treg cells, which ameliorated Th2‐mediated allergic asthma in mice. Our study supports an attractive strategy to artificially generate immunoregulatory DCs and provides a novel approach for manipulating Th2 cell‐driven deleterious immune diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Jagged1‐expressing adenovirus‐infected dendritic cells induce expansion of Foxp3⁺ regulatory T cells and alleviate T helper type 2‐mediated allergic asthma in mice

et al. 2018

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“…The role of allergy as a causative factor in asthma is also unclear. Because of the many studies that have shown strong associations of asthma with allergy phenotypes, asthma is widely considered an allergic disease (2). However, asthma often occurs in individuals who are allergen skin-test negative (3).…”

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confidence: 99%

Maternal Cytokine Profiles during Pregnancy Predict Asthma in Children of Mothers without Asthma

Rothers

Stern

Lohman

et al. 2018

Am J Respir Cell Mol Biol

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Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune Study, a nonselected birth cohort. Physician-diagnosed active asthma in children through age 9 and a history of asthma in their mothers were assessed through questionnaires. Maternal production of each of the cytokines IL-13, IL-4, IL-5, IFN-γ, IL-10, and IL-17 during pregnancy was unrelated to childhood asthma. However, IFN-γ/IL-13 and IFN-γ/IL-4 ratios during pregnancy were associated with a decreased risk of childhood asthma (n = 381; odds ratio [OR], 0.33; 95% confidence interval [CI], 0.17-0.66; P = 0.002; and n = 368; OR, 0.36; 95% CI, 0.18-0.71; P = 0.003, respectively). The inverse relations of these two ratios with childhood asthma were only evident in mothers without asthma (n = 309; OR, 0.18; 95% CI, 0.08-0.42; P = 0.00007; and n = 299; OR, 0.17; 95% CI, 0.07-0.39; P = 0.00003, respectively) and not in mothers with asthma (n = 72 and 69, respectively; P for interaction by maternal asthma = 0.036 and 0.002, respectively). Paternal cytokine ratios were unrelated to childhood asthma. Maternal cytokine ratios in mothers without asthma were unrelated to the children's skin-test reactivity, total IgE, physician-confirmed allergic rhinitis at age 5, or eczema in infancy. To our knowledge, this study provides the first evidence that cytokine profiles in pregnant mothers without asthma relate to the risk for childhood asthma, but not allergy, and suggests a process of asthma development that begins in utero and is independent of allergy.

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“…These substances might be important in the process of allergic reactions in humans. Although numerous studies have demonstrated that allergen-specific immunoglobulin E (IgE) and some food antigens can lead to anaphylaxis, [ 13 ] there are only 2 reports of the production of jellyfish-specific IgE or immunoglobulin G (IgG) antibodies in response to jellyfish stings. [ 4 , 14 ] Therefore, the underlying mechanisms linking the allergic reaction to jellyfish consumption and jellyfish stings are unclear.…”

Section: Discussionmentioning

confidence: 99%

Allergic shock caused by ingestion of cooked jellyfish

Tan

et al. 2017

Medicine

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Rationale:Although anaphylaxis caused by jellyfish stings is common in coastal areas, an allergic shock caused by cooked jellyfish ingestion has never been reported in China. In this paper, we report a case of allergic shock being caused by ingestion of cooked salt-preserved jellyfish shortly after being stung by a live jellyfish.Patient concerns:A 26-year-old Chinese man presented with dizziness, pruritus, dyspnea, hypotension, and tachycardia after eating cooked salted jellyfish. The patient had been stung twice by jellyfish half a year ago.Diagnoses:Allergic shock caused by ingestion of cooked jellyfish.Interventions:The patient was treated with phenergan (25 mg, intramuscular injection), 250 mL normal saline (NS) and 10 mg dexamethasone (intravenous drip), 500 mL NS and 0.4 g cimetidine (intravenous drip), and 500 mL NS for rapid fluid infusion (intravenous drip).Outcomes:After the treatment, the main clinical symptoms of the patient improved quickly. Five days later, the patient's urticaria had dissipated.Lessons:A history of jellyfish contact or sting might be an important allergic factor for individuals who consume any kind of jellyfish.

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How Much Asthma Is Atopic in Children?

Abstract: How Much Asthma Is Atopic in Children

Cited by 38 publications

References 37 publications

Jagged1‐expressing adenovirus‐infected dendritic cells induce expansion of Foxp3⁺ regulatory T cells and alleviate T helper type 2‐mediated allergic asthma in mice

Jagged1‐expressing adenovirus‐infected dendritic cells induce expansion of Foxp3⁺ regulatory T cells and alleviate T helper type 2‐mediated allergic asthma in mice

Maternal Cytokine Profiles during Pregnancy Predict Asthma in Children of Mothers without Asthma

Allergic shock caused by ingestion of cooked jellyfish

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How Much Asthma Is Atopic in Children?

Abstract: How Much Asthma Is Atopic in Children

Cited by 38 publications

References 37 publications

Jagged1‐expressing adenovirus‐infected dendritic cells induce expansion of Foxp3+ regulatory T cells and alleviate T helper type 2‐mediated allergic asthma in mice

Jagged1‐expressing adenovirus‐infected dendritic cells induce expansion of Foxp3+ regulatory T cells and alleviate T helper type 2‐mediated allergic asthma in mice

Maternal Cytokine Profiles during Pregnancy Predict Asthma in Children of Mothers without Asthma

Allergic shock caused by ingestion of cooked jellyfish

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Jagged1‐expressing adenovirus‐infected dendritic cells induce expansion of Foxp3⁺ regulatory T cells and alleviate T helper type 2‐mediated allergic asthma in mice

Jagged1‐expressing adenovirus‐infected dendritic cells induce expansion of Foxp3⁺ regulatory T cells and alleviate T helper type 2‐mediated allergic asthma in mice