IgE anti-respiratory syncytial virus antibodies detected in serum of pediatric patients with asthma

Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment

“…Smith‐Norowitz et al. showed that asthmatic patients ( N = 30, mean age 14 years) had greater anti‐RSV IgE antibody titers compared to non‐asthmatics ( p = 0.003) . Total serum IgE also correlated with anti‐RSV IgE titer in asthmatics ( p = 0.047) but not in non‐asthmatics ( p = 0.13) .…”

“…There are reasons to associate respiratory viral infections with atopy/allergic disease. While underappreciated, the immune response against many viral infections (not just respiratory viral infections) includes production of specific IgE (sIgE) against viral pathogens [7][8][9][10][11][12][13][14][15][16]. The significance of this anti-viral IgE is not fully understood; although, in our animal model it appears critical for translation of respiratory viral infection into atopic disease (discussed in more detail below).…”

Viruses and asthma: the role of common respiratory viruses in asthma and its potential meaning for SARS‐CoV‐2

“…That antiviral IgE may constitute a maladaptive immune response against respiratory viruses that would circumvent classical viral immune‐protective responses with a possible promotion of disseminated viral infection in the airways. In this context, it has been demonstrated in human studies that IgE against RSV is made as part of the antiviral response to RSV infection, and the levels of IgE anti‐RSV were found to be higher in asthmatic subjects compared with non‐asthmatic individuals 13 . Another study found IgE against RV in the sera of subjects who have been exposed to them 14 .…”

“…Additionally, data from different studies have revealed that in a background of atopy, IgE‐mediated reactivity against certain respiratory viruses such as respiratory syncytial virus (RSV) and human rhinovirus (RV) might exist. Although the function of IgE against viruses is still not clear, it has been suggested that it may have a role in the exacerbation of asthma induced by respiratory viruses 13,14 . In ADEH, IgE against viruses such as herpes simplex virus 1 has also been described 15 .…”

Epstein-Barr and cytomegalovirus infection as a risk factor for allergy in children with high frequency of respiratory diseases

“…Связь между перенесенной в раннем детском возрасте ОРИ, вызванной респираторно-синцитиальным, рино-или аденовирусом, и риском развития аллергических заболеваний, прежде всего, бронхиальной астмы, неоднократно обнаруживалась в исследованиях [2,3]. Ряд работ убедительно показывает роль вирусов как триггеров запуска аллергического воспаления [4,5,6]. Рост числа пациентов с аллергическими заболеваниями и тенденция к утяжелению течения таких заболеваний заставляют искать пусковые механизмы, воздействуя на которые можно было бы остановить или затормозить развитие этой социально значимой патологии.…”