IgE and Atopy in Perinatally HIV-Infected Children

Bowser, C.; Kaye, Jean; Charlot, Carole; Joks, Rauno; Moallem, J.

doi:10.1016/j.jaci.2005.12.1081

Cited by 2 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chronic spontaneous urticaria Anti-IgE therapies support the role of IgE in pathophysiology [101,151] IgE-mediated autoimmunity (systemic lupus [152], bullous pemphigoid [153], pemphigus vulgaris [154], autoimmune uveitis [155], rheumatoid arthritis [156], multiple sclerosis [157], autoimmune pancreatitis [158]) IgG4-related disease [87] Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) [88], Wegener' s granulomatosis [159], sarcoidosis [160] Viral infections [89,161] Type I hypersensitivity specific IgE to certain allergen components is a predictive biomarker for the severity of allergic reactions [49].…”

Section: Trichuriasis Enterobiasismentioning

confidence: 99%

“…Contrastingly, although elevated IgE levels in asthmatic patients with eosinophilia may suggest a diagnosis of EGPA (Eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome)), IgE levels alone are not a good predictor of EGPA disease activity [88 ]. Elevated IgE levels have been reported in patients infected with the human immunodeficiency virus (HIV), specifically in advanced stages, possibly attributed to polyclonal stimulation of B cells [89 ].…”

Section: Part 6: Other Conditions Affecting Ige Levelsmentioning

confidence: 99%

See 1 more Smart Citation

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

Ferastraoaru

Bax

Bergmann³

et al. 2020

Clin Transl Allergy

View full text Add to dashboard Cite

Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted.

show abstract

Section: Trichuriasis Enterobiasismentioning

confidence: 99%

Section: Part 6: Other Conditions Affecting Ige Levelsmentioning

confidence: 99%

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

Ferastraoaru

Bax

Bergmann³

et al. 2020

Clin Transl Allergy

View full text Add to dashboard Cite

show abstract

“…Penelitian Bowser, dkk. 11 Banyak penelitian telah dilakukan untuk mencari hubungan antara atopi, peningkatan IgE total dan penurunan jumlah limfosit CD4+, yang dilakukan baik pada dewasa maupun anak-anak. Pada penelitian ini, didapatkan prevalensi atopi pada pasien dengan HIV sebesar 54,3% dan jauh lebih tinggi dibandingkan kelompok kontrol (non-HIV).…”

Section: Diskusiunclassified

“…Sedangkan, penelitian yang melaporkan tidak terdapat peningkatan prevalensi atopi disebabkan menggunakan data penelitian lain sebagai pembanding. 11,12 Pada penelitian ini atopi dinyatakan melalui uji tusuk kulit. Sebab, uji tusuk kulit merupakan cara yang sederhana, mudah, murah dan cukup akurat.…”

Section: Diskusiunclassified

Prevalensi dan Faktor Prediktor Atopi pada Pasien HIV/AIDS Prevalence and Predictors of Atopy in HIV/AIDS Patients

Tesiman¹,

Sundaru²,

Karjadi³

et al. 2017

JPDI

View full text Add to dashboard Cite

Pendahuluan. Infeksi HIV menyerang pusat kontrol dari sistem imun yang mengakibatkan terjadinya infeksi opportunistik, keganasan dan kematian. Disregulasi dari sistem imun memegang peranan penting dalam progresifitas penyakit HIV. Beberapa penelitian melaporkan bahwa pasien-pasien HIV mempunyai kecenderungan untuk menderita penyakit alergi seperti sinusitis, asma dan dermatitis atopik. Juga dilaporkan terjadinya peningkatan kadar serum imunoglobulin E (IgE) dan peningkatan prevalensi atopi.Metode. Studi potong lintang dilakukan pada 92 orang terinfeksi HIV dan 90 orang non-HIV. Adanya atopi dinyatakan berdasarkan pemeriksaan uji tusuk kulit dengan menggunakan enam macam aeroalergen yang umum di lingkungan. Terhadap pasien-pasien yang sudah didiagnosis dengan HIV dilakukan pemeriksaan kadar IgE total, jumlah limfosit CD4 serta anamnesis terkait.Hasil. Dari 92 orang dengan infeksi HIV/AIDS dan 90 orang non-HIV yang diteliti, terdiri 65 laki-laki (70,7%) dan 27 perempuan (29,3%) pada kelompok HIV, sedangkan pada kelompok non-HIV terdiri atas 40 laki-laki (44,4%) dan 50 wanita (55,6%). Umur subjek penelitian berkisar antara 20-55 tahun dengan rerata 29,3 (5,7) tahun pada kelompok HIV, sedangkan rerata kelompok umur kontrol adalah 27,9 (4,5) tahun. Berdasarkan rute transmisi HIV, didapatkan sebanyak 52 subjek melalui penggunaan obat intravena (56,5%), 35 melalui hubungan seksual (38%) sedangkan sisanya (5,5%) mempunyai risiko keduanya. Jumlah limfosit CD4+ berkisar 2-674 sel/uL dengan median 160 sel/uL. Kadar IgE total berkisar dari 3-20.000 IU/ mL dengan median 283,5 IU/mL. Kejadian atopi lebih tinggi pada subjek dengan HIV dibandingkan dengan kelompok non-HIV (p= 0,001). Aeroalergen tersering yang menimbulkan sensitasi adalah Dermatophagoides farinae sebanyak 50% dan Dermatophagoides pteronyssinus sebanyak 30%. Didapatkan adanya korelasi negatif yang bermakna antara jumlah limfosit CD4+ dengan kadar IgE total (r=-0,544, p<0,001). Namun demikian, tidak didapatkan hubungan yang bermakna antara jenis kelamin, rute transmisi, riwayat alergi di keluarga serta jumlah limfosit CD4+ dengan kejadian atopi.Simpulan. Prevalensi atopi pada pasien HIV/AIDS berdasarkan uji tusuk kulit lebih tinggi dibanding kelompok non-HIV. Terdapat korelasi negatif antara kadar IgE total dengan jumlah limfosit CD4+.Kata kunci: atopi, HIV, tes tusuk kulitPrevalence and Predictors of Atopy in HIV/AIDS PatientsIntroduction. HIV infection attacks the center of immune control system resulting opportunistic infection, malignancy and death. Immune system dysregulation plays the central role in the progression of the disease. Some studies reported that HIV-infected patient prone to have allergic disease such as sinusitis, asthma and atopic dermatitis. Elevated serum immunoglobulin E (IgE) and increased prevalence of atopy had also been reported in HIV-infected patient. Methods. A cross sectional study was performed in 92 HIV-infected persons and 90 non-HIV persons. Atopy diagnosis was based on immediate hypersensitivity to six common aeroallergen using skin prick test. CD4 cell count, total serum immunoglobulin level and medical history were taken. Results. Among total of 92 HIV/AIDS patients and 90 non-HIV persons, there were 65 males (70.7%) and 27 female (29.3%) in HIV group and 40 males (44.4%) and 50 females (55.6%) in non-HIV group. Age of all subjects range from 20 to 55 years old, mean age of HIV-infected patients was 29.3 (SD 5.7) years while mean age of controls was 27.9 (4.5) years old. Based on HIV route transmission, there were 56.5% subjects infected from intravenous drug user, 38% from heterosexual intercourse and 5.5% subjects had both risk. CD4+ lymphocyte counts of the subject range from 2-674 cells, median 160 cells/uL. Serum total IgE levels range from 3-20.000 IU/mL with median 283.5 IU/mL. Atopy was higher in subjects with HIV than non-HIV (p= 0,001). The most common aeroallergen is Dermatophagoides farinae (50%) and Dermatophagoides pteronyssinus (30%). There was a negative correlation between CD4+ lymphocyte count and total IgE level (r=-0,544, p<0,001), but there is no relation between gender, HIV route of transmission, allergic history in family and CD4+ lymphocyte count with atopy. Conclusions. Prevalence of atopy based on skin prick test among HIV/AIDS patients was higher than non-HIV group. There was a negative correlation between CD4+ lymphocyte count and total IgE level. Keywords: atopy, CD4, HIV, IgE

show abstract

IgE and Atopy in Perinatally HIV-Infected Children

Cited by 2 publications

References 0 publications

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

Prevalensi dan Faktor Prediktor Atopi pada Pasien HIV/AIDS Prevalence and Predictors of Atopy in HIV/AIDS Patients

Contact Info

Product

Resources

About