IgA/IgG Pemphigus with Infiltration of Neutrophils and Eosinophils in an Ulcerative Colitis Patient

Clinicopathologic features of IgG/IgA pemphigus in comparison with classic (IgG) and IgA pemphigus

“…1,2 In recent years, approximately 26 reports of IgG/IgA pemphigus, defined by the presence of IgG and IgA cell surface deposits upon direct immunofluorescence (DIF) and/or circulating IgG and IgA autoantibodies upon indirect immunofluorescence (IIF), have been published. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] These previous reports have shown that these patients may display clinical and microscopic features resembling those of PV, PF, pemphigus herpetiformis, or IgA pemphigus, or may be unique. There is currently no consensus on whether IgG/IgA pemphigus represents a separate variant of pemphigus or not.…”

IgG/IgA-pemphigus — extremely rare blistering autoimmune diseases

“…В ряде случаев в очагах поражения кожи у больных IgG/IgA-пузырчаткой в составе инфильтрата преобладали лимфоциты [32]. Отмечалось также присутствие в инфильтрате эозинофилов [15,17]. Описан больной, у которого в эпидермисе обнаруживались клетки с признаками дискератоза [29].…”

“…В литературе описано сочетание IgG/IgA-пузырчатки с другими аутоиммунными заболеваниями -синдромом Шегрена, язвенным колитом, миастенией [12,16,17]. У больных IgG/IgA-пузырчаткой выявляли также различные новообразования: рак поджелудочной железы, яичников, эндометрия, желчного пузыря и легкого, лимфопролиферативные заболевания, IgA-гаммапатии [3,16,[18][19][20][21][22].…”

Cutaneous implantation of papillary thyroid carcinoma secondary to percutaneous ethanol injection into nodal metastasis

“…In patients with limited cervical lymph node metastases who are not candidates for surgery or radioiodine therapy, percutaneous ethanol injection (PEI) guided by ultrasonography has proven to be a valuable treatment alternative. 1,2 While skin metastases of papillary thyroid carcinoma seem to be an extremely rare finding, a few cases of cutaneous implantation after fine needle aspiration biopsy (FNAB) 3,4 and thyroidectomy 5 have been reported. However, we have not found any previous cases of implantation of skin metastasis after therapeutic PEI into affected nodes.…”

“…The coexistence of autoimmune bullous disorders and ulcerative colitis has been previously reported, 2 including epidermolysis bullosa acquisita, 3 linear IgA disease 4 and rarely IgA pemphigus. 5 There is only …”