Clinicopathologic features of <scp>I</scp>g<scp>G</scp>/<scp>I</scp>g<scp>A</scp> pemphigus in comparison with classic (<scp>I</scp>g<scp>G</scp>) and <scp>I</scp>g<scp>A</scp> pemphigus

Toosi, Siavash; Collins, Jeffrey W.; Lohse, Christine M.; Wolz, Michael; Wieland, C; Camilleri, Michael; Bruce, Alison J.; McEvoy, Marian T.; Lehman, Julia S.

doi:10.1111/ijd.13025

Cited by 22 publications

(27 citation statements)

References 31 publications

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“…This allows the conclusion that the buttock does not belong to a true special body site. 2,3 In fact, our casuistic confirms the results of a previous smaller report performed by Abadir et al 1 in 1995, in which the authors did not observe atypical features in melanocytic naevi of the buttocks.These results highlight that other pathways are involved in the pathogenesis of melanocytic lesions in this hidden body site. 4…”

supporting

confidence: 91%

“…In recent years, cases of IgG/IgA pemphigus, a rare subtype of pemphigus characterized by circulating IgG and IgA autoantibodies against the keratinocyte cell surface, have been reported. [1][2][3][4][5][6] The cutaneous manifestations of IgG/IgA pemphigus were reported to resemble those of IgA pemphigus in form, including the presence of pustules and annular lesions. 1 However, no consensus on what eruptions are typical of IgG/IgA pemphigus has been established, due to the rarity of this disease.…”

Section: Editormentioning

confidence: 99%

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Crusted impetigo‐like lesion on the face: a case of IgG/IgA pemphigus

Moriuchi

Ito

Kikuchi

et al. 2016

Acad Dermatol Venereol

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supporting

confidence: 91%

Section: Editormentioning

confidence: 99%

Crusted impetigo‐like lesion on the face: a case of IgG/IgA pemphigus

Moriuchi

Ito

Kikuchi

et al. 2016

Acad Dermatol Venereol

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“…Reported sites of involvement range from the trunk as the sole site of involvement to the whole body and oral mucosa as well as the conjunctiva and esophagus . Pathologic manifestations range from IgA pemphigus‐like pustular eruptions to a pemphigus foliaceus (PF) or pemphigus vulgaris (PV)‐like appearance . IgG/IgA pemphigus may not respond to the same treatments as IgG pemphigus.…”

mentioning

confidence: 99%

IgG/IgA pemphigus in a patient with a history of pemphigus vulgaris: An example of epitope spreading?

et al. 2019

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We report a case of IgG/IgA pemphigus presenting as pemphigus foliaceus following diagnosis and treatment of classic IgG‐mediated pemphigus vulgaris. The dual presentation of IgG and IgA positivity on direct immunofluorescence (DIF) constitutes a rare form of pemphigus with a wide variety of clinicopathologic manifestations. The progression of pemphigus vulgaris is commonly because of epitope spreading. However, the patient's disease was partially refractory to rituximab and showed a change in the DIF with dual staining for IgG and IgA. This indicates that class‐switching may have occurred with epitope spreading or that there was autoreactive IgA at the onset of disease below the threshold of detection by DIF. Our case indicates that in progressive autoimmune disease refractory to treatment, re‐evaluation of the patient for antibody isotypes absent on initial diagnosis may offer key information in better identifying the cause of progression as well as in directing the necessary treatment.

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“…IAP in turn is divided into two subtypes: subcorneal pustular dermatosis (s‐c) in which Dsc1 is the target antigen; and intra‐epidermal neutrophilic dermatosis (i‐e) in which the targets are Dsg1 and Dsg3 (Kneisel and Hertl, ). Recently, a comparative clinicopathological study described an IgG/IgA pemphigus that is a further overlapping variant between classic IgG pemphigus and IAP, and may be best regarded as a variant of IgG pemphigus as it is distinct from IgA pemphigus (Toosi et al, ). Histologically, IAP is characterized by acantholysis and extensive neutrophilic infiltration within the epidermis (Tsuruta et al, ).…”

Section: Desmosome Diseasesmentioning

confidence: 99%

Pathophysiology of the Desmo-Adhesome

et al. 2016

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Advances in our understanding of desmosomal diseases have provided a clear demonstration of the key role played by desmosomes in tissue and organ physiology, highlighting the importance of their dynamic and finely regulated structure. In this context, non-desmosomal regulatory molecules have acquired increasing relevance in the study of this organelle resulting in extending the desmosomal interactome, named the "desmo-adhesome." Spatiotemporal changes in the expression and regulation of the desmo-adhesome underlie a number of genetic, infectious, autoimmune, and malignant conditions. The aim of the present article was to examine the structural and functional relationship of the desmosome, by providing a comprehensive, yet focused overview of the constituents targeted in human disease. The inclusion of the novel regulatory network in the desmo-adhesome pathophysiology opens new avenues to a deeper understanding of desmosomal diseases, potentially unveiling pathogenic mechanisms waiting to be explored. J. Cell. Physiol. 232: 496-505, 2017. © 2016 Wiley Periodicals, Inc.

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Clinicopathologic features of IgG/IgA pemphigus in comparison with classic (IgG) and IgA pemphigus

Abstract: Comparative clinicopathologic data imply that IgG/IgA pemphigus may best be regarded as a variant of IgG pemphigus and distinct from IgA pemphigus.

Cited by 22 publications

References 31 publications

Crusted impetigo‐like lesion on the face: a case of IgG/IgA pemphigus

Crusted impetigo‐like lesion on the face: a case of IgG/IgA pemphigus

IgG/IgA pemphigus in a patient with a history of pemphigus vulgaris: An example of epitope spreading?

Pathophysiology of the Desmo-Adhesome

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