IgA ANTIBODIES TO<i>CHLAMYDIA TRACHOMATIS</i>AND SEMINAL PARAMETERS IN ASYMPTOMATIC INFERTILE MALES

Videaú, S. Penna; Vivas, Jorge; Salazar, Natalia

doi:10.1080/01485010151096469

Cited by 20 publications

(1 citation statement)

References 29 publications

(48 reference statements)

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“…[1112] The prevalence of asymptomatic CT has been estimated at 20% in men with iOAT. [1314] As this percentage is higher than in the control population, asymptomatic CT infection has been regarded by some as a cause of iOAT. However, other researchers have found the CT prevalence (of approximately 5%) to be similar among iOAT and fertile subjects.…”

Section: Idiopathic Oligoasthenoteratozoospermiamentioning

confidence: 98%

Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified?

Agarwal¹,

Sekhon²

2011

Indian J Urol

113

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Oxidative stress contributes to defective spermatogenesis and the poor quality of sperm associated with idiopathic male factor infertility. The aim of this study was to review the current literature on the effects of various types of antioxidant supplements in patients to improve fertilization and pregnancy rates in subfertile males with idiopathic oligoasthenoteratozoospermia (iOAT). Review of recent publications through PubMed and the Cochrane database. Oxidative stress is implicated in impaired spermatogenesis leading to the poor semen parameters and increased DNA damage and apoptosis in iOAT. Strategies to modulate the level of oxidative stress within the male reproductive tract include the use of oral antioxidant compounds to reinforce the body's defence against oxidative damage. In our evaluation, carnitines were considered the most established pharmacotherapeutic agent to treat iOAT, as evidence and data concerning carnitine supplementation have been shown to be most consistent and relevant to the population of interest. Other therapies, such as combined vitamin E and C therapy, are still considered controversial as vitamin C can act as a pro-oxidant in certain instances and the results of randomized controlled trials have failed to show significant benefit to sperm parameters and pregnancy rates. There is a need for further investigation with randomized controlled studies to confirm the efficacy and safety of antioxidant supplementation in the medical treatment of idiopathic male infertility as well as the need to determine the dosage required to improve semen parameters, fertilization rates and pregnancy outcomes in iOAT.

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Section: Idiopathic Oligoasthenoteratozoospermiamentioning

confidence: 98%

Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified?

Agarwal¹,

Sekhon²

2011

Indian J Urol

113

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Sexual Issues: Role of Sexually Transmitted Infections on Male Factor Fertility

et al. 2014

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Risk factors on testicular function in adolescents

Cargnelutti

Nisio

Pallotti

et al. 2022

J Endocrinol Invest

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Purpose Adolescence represents an important window for gonadal development. The aim of this review is to carry out a critical excursus of the most recent literature on endogenous and exogenous risk factors related to testicular function, focusing the research on adolescence period. Methods A comprehensive literature search within PubMed was performed to provide a summary of currently available evidence regarding the impact on adolescence of varicocele, cryptorchidism, cancer, diabetes, lifestyle factors, endocrine disruptors, obesity and sexually transmitted diseases. We focused on human studies that evaluated a possible impact of these factors on puberty timing and their effects on andrological health. Results Evidence collected seems to suggest that andrological health in adolescence may be impaired by several factors, as varicocele, cryptorchidism, and childhood cancer. Despite an early diagnosis and treatment, many adolescents might still have symptoms and sign of a testicular dysfunction in their adult life and at the current time it is not possible to predict which of them will experience andrological problems. Lifestyle factors might have a role in these discrepancies. Most studies point out towards a correlation between obesity, insulin resistance, alcohol, smoking, use of illegal drugs and testicular function in pubertal boys. Also, endocrine disruptors and sexually transmitted diseases might contribute to impair reproductive health, but more studies in adolescents are needed. Conclusion According to currently available evidence, there is an emerging global adverse trend of high-risk and unhealthy behaviors in male adolescents. A significant proportion of young men with unsuspected and undiagnosed andrological disorders engage in behaviors that could impair testicular development and function, with an increased risk for later male infertility and/or hypogonadism during the adult life. Therefore, adolescence should be considered a key time for intervention and prevention of later andrological diseases.

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IgA ANTIBODIES TOCHLAMYDIA TRACHOMATISAND SEMINAL PARAMETERS IN ASYMPTOMATIC INFERTILE MALES

Cited by 20 publications

References 29 publications

Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified?

Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified?

Sexual Issues: Role of Sexually Transmitted Infections on Male Factor Fertility

Risk factors on testicular function in adolescents

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