IgA anti-single stranded DNA antibodies and IgA-containing circulating immune complexes (IgA-CIC) in MRL mice.

学而, 大塩; 福実, 古川; 均, 田中; 憲一, 関田; 義博, 濱島

doi:10.2492/jsir1981.5.103

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Light-microscopical Findings1

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1987

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“…We found high levels of mitochondria-binding antibodies and age-related variations in the antibodies in MRL1/1 mice. The same age-related variations were detected in anti-ssDNA antibodies in MRL1 /1 mice (19). Although the levels of anti-mitochondrial antibodies were high in MRL1/1 mice, there was no evidence of primary biliary cirrhosis.…”

Section: Light-microscopical Findingssupporting

confidence: 66%

High Levels of Anti‐Mitochondrial Antibodies in MRL Mice Influence of Anti‐DNA Antibodies on Anti‐Mitochondrial Antibodies Measured by an Enzyme‐Linked Immunosorbent Assay

Ohshio¹,

Furukawa²,

Yoshioka³

et al. 1987

Microbiology and Immunology

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We developed an easy enzyme-linked immunosorbent assay (ELISA) for anti-mitochondrial antibodies, and detected high levels of anti-mitochondrial antibodies in MRL/Mp-lpr/lpr (MRL1 /1) mice. The influence of the presence of anti-DNA antibodies in the tested sera on this assay was also evaluated. The monoclonal anti-DNA antibodies, which were made from non-immunized MRL1 /1 mice, did not react with the mitochondrial antigens adhering to polystyrene plates. Absorption with DNA had little effect on the levels of mitochondrial antibodies in MRL1 /1 sera. Our assay for mitochondria-binding antibody was very easy and sensitive, although it could not differentiate among heterogeneous anti-mitochondrial antibodies.

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Section: Light-microscopical Findingssupporting

confidence: 66%