“…Other approaches, targeting the biomolecular aspects of the healing process, might be useful in achieving further progress in decreasing adhesion formation and optimizing the recovery and strength of flexor tendon repair. [1][2][3][4] Growth factors and inflammatory agents have been the major focus of research, but no single factor has yet proven to be the ultimate solution to either limit adhesion formation or augment tendon strength. The relative importance of different molecular and cellular participants during different phases, as well as potential negative effects of manipulation with down-regulation or up-regulation of a certain factor still remain, to a large extent, unknown.…”