IFNα and its response proteins, IP-10 and SIGLEC-1, are biomarkers of disease activity in systemic lupus erythematosus

Biomarkers in systemic lupus erythematosus: challenges and prospects for the future

“…Other investigators have subsequently reported similar findings, including significant associations of enhanced expression of IFN-inducible genes and/ or serum levels of IFN-inducible chemokines with increased disease activity, organ involvement, hypocomplementemia, and the presence of autoantibodies specific for dsDNA and RNAbinding proteins (Ro, U1-RNP, and Sm), in both adult and pediatric SLE patients [Bauer et al 2006;Bennett et al 2003;Feng et al 2006;Kirou et al 2005;Nikpour et al 2008;Vila et al 2007]. Two independent studies utilizing transcriptome analysis and traditional techniques [enzymelinked immunosorbent assay (ELISA) and flow cytometry] demonstrated that IP-10 and sialic acid-binding Ig-like lectin 1 (SIGLEC-1) were among the most prominent type 1 IFN-regulated genes/proteins [Biesen et al 2008;Rose et al 2012]. Increased serum levels of IP-10 and SIGLEC-1 were detected in 50% and 86%, respectively, of patients with active SLE [Rose et al 2012].…”

“…Two independent studies utilizing transcriptome analysis and traditional techniques [enzymelinked immunosorbent assay (ELISA) and flow cytometry] demonstrated that IP-10 and sialic acid-binding Ig-like lectin 1 (SIGLEC-1) were among the most prominent type 1 IFN-regulated genes/proteins [Biesen et al 2008;Rose et al 2012]. Increased serum levels of IP-10 and SIGLEC-1 were detected in 50% and 86%, respectively, of patients with active SLE [Rose et al 2012]. The serum IP-10 and SIGLEC-1 levels correlated positively with disease activity and anti-dsDNA antibody levels, but inversely with serum complement levels [Biesen et al 2008].…”

Autoantibodies, complement and type I interferon as biomarkers for personalized medicine in SLE

“…In comparison, ANuA are elevated in 23% of inactive and in 63% of highly active SLE patients. 29 Regarding the correlation of anti-dsDNA antibodies with disease activity over time, contradictory reports have been published in the literature. The published findings range from a positive correlation 30 to no correlation 31 to a negative correlation.…”

Biomarkers for systemic lupus erythematosus: an update

“…These serum chemokine levels correlated with SLEDAI, and also predicted future disease flares. A recent study showed IFN-α, CXCL10 (IP-10) and sialic acid binding immunoglobulin-like lectin-1 have been significantly correlated with SLEDAI and BILAG [41].…”