IFNα-2a protects mice against a helminth infection of the liver and modulates immune responses

Godot, Véronique; Harraga, S.; Podoprigora, G. I.; Liance, M.; Bardonnet, Karine; Vuitton, Dominique A.

doi:10.1016/s0016-5085(03)00273-7

Cited by 59 publications

(40 citation statements)

References 34 publications

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“…So far, most groups agreed that secondary murine AE includes a mixed Th1/Th2 response, so the working hypothesis discussed by several authors was that partial protection (=reduced metacestode proliferation) may be associated with a rather Th1-orientation of immune response. A Th2-orientation may be in favour of metacestode proliferation (Amiot et al 1999;Emery et al 1996;Godot et al 2003;Jenne et al 1998;Liance et al 1998). …”

Section: Discussionmentioning

confidence: 99%

Gerbu adjuvant modulates the immune response and thus the course of infection in C56BL/6 mice immunised with Echinococcus multilocularis rec14-3-3 protein

Margos

Gottstein

2010

Parasitol Res

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Vaccination with Echinococcus multilocularis 14-3-3 protein can protect mice against primary E. multilocularis infection. The present study investigated the efficacy and efficiency of the adjuvant muramyl dipeptide Gerbu, alone or together with recombinant 14-3-3 protein, to modulate the course of secondary E. multilocularis infection in C56BL/6 mice. The application of Gerbu alone already resulted in a parasite weight reduction when compared with infected control mice, while rec14-3-3 did not add to this effect. Immunological parameters were concurrently assessed with a mixed cell reaction including bone marrow-derived dendritic cells (BMDCs) together with lymph node cells from mice with or without immunisation and/or infection. While mice having received Gerbu adjuvant were found to highly proliferate in response to co-cultivation with 14-3-3-stimulated bone marrow dendritic cells, a sensitisation of BMDCs with vesicle fluid (VF) antigen lead to a striking decrease of the lymphoproliferative response in comparison to that of control mice, raising the hypothesis that immunosuppressive components may be part of this VF-antigen. Anti-14-3-3 antibody production was only found in those mice that had been previously 14-3-3-immunised, whereas all other only-infected mice failed to produce such antibodies. Conclusively, Gerbu adjuvant appears to directly generate a non-specific immune response that contributes to the control of the metacestode growth, putatively in association with a BMDC activity suppressed by components of the VF-antigen.

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Section: Discussionmentioning

confidence: 99%

Gerbu adjuvant modulates the immune response and thus the course of infection in C56BL/6 mice immunised with Echinococcus multilocularis rec14-3-3 protein

Margos

Gottstein

2010

Parasitol Res

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“…In contrast, the treatment with IFN-gamma 5 micrograms daily twice a week increased the liver metacestode load. Godot et al (2003) analysed the effects of recombinant IFN alpha-2a in the susceptible C57BL/6J Echinococcus multilocularis infected mice. After 90 days post-infection, 75% of infected IFN alpha2a-treated mice had no hepatic lesions and half were fully protected.…”

Section: Discussionmentioning

confidence: 99%

Regression of alveolar echinococcosis after chronic viral hepatitis C treatment with pegylated interferon alpha 2a

Dražilová¹,

Kinčeková

Beňa³

et al. 2012

Helminthologia

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We present a case of 53 years old patient with transplanted kidney, chronic hepatitis C and alveolar echinococcosis who was treated with pegylated interferon α which resulted in regression and calcification of Echinococcus multilocularis loculi. Patient had been diagnosed with chronic hepatitis C two years after kidney transplantation. Hepatitis was left untreated because of immunosuppressive treatment and satisfactory graft function. Nine years after transplantation the patient was diagnosed with alveolar echinococcosis and treated with mebendazole 2 × 200 mg daily for 6 months. Cessation of temporary treatment resulted in echinococcosis progression with appearance of secondary loculi and a small ascites after which mebendazole was restarted. Ten years after transplantation, kidney graft failure occurred and the patient was started on hemodialysis in conjunction with pegylated-interferon alpha 2a for treatment of chronic viral hepatitis C. Complete early viral response was observed 3 months after therapy initiation while a follow-up CT scan after 4 months did not document any changes in the number or size of E. multilocularis loculi. A completed course of antiviral therapy resulted in sustained viral response while a subsequent second follow-up CT scan 6 months after cessation of antiviral therapy documented regression and calcification of main E. multilocularis loculi along with resolution of secondary loculi and ascites.

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“…Amphotericin B as salvage treatment for AE patients with intolerance or resistance to benzimidazoles effectively halted parasite progression in a small series of patients, but its IV administration precludes its use for the treatment of a chronic disease (Reuter et al 2003). Because of the exquisite sensitivity of Echinococcus larvae to the immune response of the host, efficacy of immune therapy may be anticipated; the only proof of concept was given a decade ago for interferon-alpha, with nearly complete prevention of E. multilocularis infection in experimental mice, and impressive regression of hepatic lesions in a patient with AE (Harraga et al 1999;Godot et al 2003) however, no clinical trials have been implemented to confirm these preliminary successes.…”

Section: Side Effects Of Benzimidazolesmentioning

confidence: 99%

Cystic and Alveolar Echinococcosis: Fraternal Twins both in Search of Optimal Treatment

Vuitton

Brunetti

2014

Zoonoses - Infections Affecting Humans and Animals

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IFNα-2a protects mice against a helminth infection of the liver and modulates immune responses

Cited by 59 publications

References 34 publications

Gerbu adjuvant modulates the immune response and thus the course of infection in C56BL/6 mice immunised with Echinococcus multilocularis rec14-3-3 protein

Gerbu adjuvant modulates the immune response and thus the course of infection in C56BL/6 mice immunised with Echinococcus multilocularis rec14-3-3 protein

Regression of alveolar echinococcosis after chronic viral hepatitis C treatment with pegylated interferon alpha 2a

Cystic and Alveolar Echinococcosis: Fraternal Twins both in Search of Optimal Treatment

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