IFNG-AS1 Enhances Interferon Gamma Production in Human Natural Killer Cells

Stein, Natan; Berhani, Orit; Schmiedel, Dominik; Duev-Cohen, Alexandra; Seidel, Einat; Kol, Inbal; Tsukerman, Pinchas; Hecht, Merav; Reches, Adi; Gamliel, Moriya; Obeidat, Akram; Charpak-Amikam, Yoav; Yamin, Rachel; Mandelboim, Ofer

doi:10.1016/j.isci.2018.12.034

Cited by 42 publications

(32 citation statements)

References 46 publications

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“… 38 , 39 It could also promote IFN-γ production in nature killer cells and suppress cancer progress. 40 It is suggested that the 8 lncRNAs could affect the immune response of CC patients.…”

Section: Discussionmentioning

confidence: 99%

Identification and Experimental Validation of Immune-Associate lncRNAs for Predicting Prognosis in Cervical Cancer

Ye¹,

Chen²,

Lü³

2021

OTT

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Purpose: Cervical cancer (CC) is a major risk for health of modern women. Immune-related long non-coding RNAs (lncRNAs) can also serve as prognostic markers of overall survival (OS) in patients with CC. This study aimed to identify an immune-related lncRNA signature for the prospective assessment of prognosis in CC patients. Methods: We first calculated immune scores of CC patients in the Cancer Genome Atlas (TCGA) database. Univariate Cox, Lasso Cox and multivariate Cox regression analyses were perfumed to establish an immune-relative lncRNA signature. In addition, we processed pathway enrichment analysis and immune infiltration analysis between patients with higher or lower risk. Finally, T-cell Chemotaxis assays were processed to verify the function of 2 key lncRNAs. Results: Our results suggested that patients with higher immune scores had longer survival time and some lncRNAs expressed differentially between two groups. Eight lncRNAs (LINC02802, LINC01877, RBAKDN, LINC02480, WWC2-AS2, LINC01281, ZBTB20-AS1, IFNG-AS1) were identified as prognostic signatures for CC. The immune-related lncRNA signature was correlated with disease progression and worse prognosis. Immune infiltration analysis indicated that the expression of 8-lncRNA signatures were corrected with infiltration level of immune cell subtypes. In addition, T-cell Chemotaxis assay validated that 2 key lncRNAs (ZBTB20-AS1 and LINC01281) could significantly promote the migration ability of T cells to CC cells. Conclusion: Our finding demonstrated the value of lncRNAs in evaluating the immune infiltrate of the tumor. The 8-lncRNA signature could predict the prognosis of CC and contribute to decisions regarding the immunotherapeutic strategy.

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Section: Discussionmentioning

confidence: 99%

Identification and Experimental Validation of Immune-Associate lncRNAs for Predicting Prognosis in Cervical Cancer

Ye¹,

Chen²,

Lü³

2021

OTT

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“…Natural killer (NK) cells are the major innate lymphocytes [ 11 , 12 , 13 , 14 ]. NK cells mediate cytotoxicity [ 15 , 16 , 17 , 18 , 19 ] and produce significant quantities of inflammatory cytokines, including interferon-γ (IFN-γ) [ 20 , 21 , 22 , 23 , 24 ] and tumor necrosis factor-alpha (TNF-α) [ 25 , 26 , 27 , 28 ]. Our knowledge about the molecular basis of the development and functions of NK cells is progressing rapidly.…”

Section: Introductionmentioning

confidence: 99%

Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance

Hashemi

Malarkannan

2020

Cancers

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Natural killer (NK) cells belong to type 1 innate lymphoid cells (ILC1) and are essential in killing infected or transformed cells. NK cells mediate their effector functions using non-clonotypic germ-line-encoded activation receptors. The utilization of non-polymorphic and conserved activating receptors promoted the conceptual dogma that NK cells are homogeneous with limited but focused immune functions. However, emerging studies reveal that NK cells are highly heterogeneous with divergent immune functions. A distinct combination of several activation and inhibitory receptors form a diverse array of NK cell subsets in both humans and mice. Importantly, one of the central factors that determine NK cell heterogeneity and their divergent functions is their tissue residency. Decades of studies provided strong support that NK cells develop in the bone marrow. However, evolving evidence supports the notion that NK cells also develop and differentiate in tissues. Here, we summarize the molecular basis, phenotypic signatures, and functions of tissue-resident NK cells and compare them with conventional NK cells.

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“…The long non-coding RNA Tmevpg1, also known as NeST or IFNG-AS1, has also been implicated in regulating IFNγ production 153 . A recent publication identified a unique Accepted Article isoform expressed in human NK cells that impacted IFNγ transcription and secretion 154 , indicating regulation on a transcriptional rather than translational level. NK cell receptor-mediated IFNγ production has been well established in in vitro models, but its role during virus infections in vivo remains largely unexplored.…”

Section: Accepted Articlementioning

confidence: 99%

Natural killer cell effector functions in antiviral defense

Piersma

Brizić

2021

The FEBS Journal

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Abbreviations: antibody-dependent cytotoxicity (ADCC); UA-rich elements (ARE); cyclic GMP-AMP synthase (cGAS); conserved non-coding sequence 1 (CNS1); DNAX accessory molecule 1 (DNAM-1); hepatitis B virus (HBV); hepatitis C virus (HCV); interferon (IFN); type I IFN (IFN-I); innate lymphoid cells (ILCs); interleukin (IL); killer cell immunoglobulin-like receptors (KIR); Accepted ArticleThis article is protected by copyright. All rights reserved lymphocyte-activation gene 3 (LAG-3); leukocyte immunoglobulin-like receptors (LILRs); murine cytomegalovirus (MCMV); major histocompatibility complex (MHC); MHC class I chain-related protein (MIC); murine UL16-binding protein-like transcript 1 (MULT1); natural cytotoxic receptor 1 (Ncr1); natural killer (NK); natural killer group 2D (NKG2D); programmed cell death 1 (PD-1); pattern recognition receptors (PRRs); poliovirus receptor (PVR); retinoic acid early inducible gene 1 (Rae-1); signaling lymphocytic activation molecule (SLAM); signal transducer and activator of transcription (STAT); stimulator of interferon gene (STING); T helper (Th); T cell immunoreceptor with Ig and ITIM domains (TIGIT); T-cell immunoglobulin mucin receptor 3 (TIM-3); TIR-domaincontaining adapter-inducing interferon-β (TRIF); toll like receptors (TLRs); UL16 binding protein (ULBP); untranslated region (UTR); vaccinia virus (VACV).

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IFNG-AS1 Enhances Interferon Gamma Production in Human Natural Killer Cells

Cited by 42 publications

References 46 publications

Identification and Experimental Validation of Immune-Associate lncRNAs for Predicting Prognosis in Cervical Cancer

Identification and Experimental Validation of Immune-Associate lncRNAs for Predicting Prognosis in Cervical Cancer

Tissue-Resident NK Cells: Development, Maturation, and Clinical Relevance

Natural killer cell effector functions in antiviral defense

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