Idiopathic pulmonary fibrosis—results from a Japanese nationwide epidemiological survey using individual clinical records

Ohno, Shoji; Nakaya, Takakiyo; Bando, Masashi; Sugiyama, Yukihiko

doi:10.1111/j.1440-1843.2008.01349.x

Cited by 39 publications

(27 citation statements)

References 6 publications

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“…Our study is the first to present the prevalence of typical CPFE patterns on chest CT images in patients with MPA. Although the exact prevalence of CPFE in the Japanese population is not known, the prevalence of typical CPFE patterns in MPA patients in our study (4%) is much higher than that of idiopathic interstitial pneumonias estimated in the Japanese population (0.0023-0.0034%) (33,34).…”

Section: Discussioncontrasting

confidence: 66%

Prevalence and Responsiveness to Treatment of Lung Abnormalities on Chest Computed Tomography in Patients With Microscopic Polyangiitis: A Multicenter, Longitudinal, Retrospective Study of One Hundred Fifty Consecutive Hospital‐Based Japanese Patients

Yamagata

Ikeda

Tsushima

et al. 2016

Arthritis & Rheumatology

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Objective. To determine the prevalence of lung abnormalities on chest computed tomography (CT) in patients with microscopic polyangiitis (MPA), to assess the responsiveness of such abnormalities to initial treatment, and to assess associations between these abnormalities and patient and disease characteristics and mortality.Methods. We retrospectively identified 167 consecutive hospital-based patients with MPA in 3 hospitals in Japan. We longitudinally collected clinical information for 150 of these patients, for whom CT images obtained before treatment were available. We then determined the presence of 22 imaging components of lung abnormalities in these patients.Results. The vast majority of patients (97%) had at least 1 lung abnormality on chest CT images, including interstitial lung lesions (66%), airway lesions (66%), pleural lesions (53%), and emphysematous lesions (37%). In multivariate analyses, ground-glass opacity was associated with the Birmingham Vasculitis Activity Score, whereas 3 of 4 airway lesions were associated with myeloperoxidase-antineutrophil cytoplasmic antibodies. Latent class analysis identified a distinct group of patients with airwaypredominant lung lesions. Airway lesions such as bronchiolitis and bronchovascular bundle thickening were among the components that showed improvement within 3 months of the initial treatment. An idiopathic pulmonary fibrosis pattern was the only chest CT variable that was independently associated with shorter survival.Conclusion. Abnormalities in a wide range of anatomic areas, including the whole airway, can be identified in the lungs of patients with MPA before treatment. The prevalence, clustering patterns, and responsiveness to treatment of individual lung abnormalities provide groundwork for informing future studies to understand the pathophysiology of MPA.Microscopic polyangiitis (MPA) is a necrotizing systemic vasculitis that affects small to medium-sized vessels. In MPA, immune deposits on the vessel wall are usually absent, and serum antineutrophil cytoplasmic antibodies (ANCAs) are frequently present. MPA shares these

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Section: Discussioncontrasting

confidence: 66%

Prevalence and Responsiveness to Treatment of Lung Abnormalities on Chest Computed Tomography in Patients With Microscopic Polyangiitis: A Multicenter, Longitudinal, Retrospective Study of One Hundred Fifty Consecutive Hospital‐Based Japanese Patients

Yamagata

Ikeda

Tsushima

et al. 2016

Arthritis & Rheumatology

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show abstract

“…For example, the contrast between the proportion of deaths due to 'unspecified' interstitial lung disease in Japan (70-75%) and elsewhere (10-20%) warrants further exploration. Previous literature has suggested a lower incidence of IPF in East Asia (19,20) although this likely relates to sampling of insurance databases featuring mainly severe disease. Assessment of data from other countries in East…”

Section: Discussionmentioning

confidence: 96%

Increasing Global Mortality from Idiopathic Pulmonary Fibrosis in the Twenty-First Century

Hutchinson

McKeever²,

Fogarty³

et al. 2014

Annals ATS

172

132

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“…Different studies have reported a varying prevalence of IPF from 1.25 to 27.9 cases per 100,000 (5)(6)(7)(8)(9)(10)(11)(12), as shown in Figure 1. A study in the United Kingdom estimated that the incidence of IPF increased by 11% annually from 1991 to 2003 (13).…”

Section: General Condition and Epidemiologymentioning

confidence: 98%

Idiopathic pulmonary fibrosis: The current status of its epidemiology, diagnosis, and treatment in China

Huang

Peng

Zhong

2013

Intractable Rare Dis Res

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Idiopathic pulmonary fibrosis—results from a Japanese nationwide epidemiological survey using individual clinical records

Abstract: Nationwide epidemiological survey of patients with idiopathic pulmonary fibrosis using clinical personal records in Japan OHNO S, NAKAYA T, BANDO M, SUGIYAMA Y. Respirology 2008; 13: 926-928

Cited by 39 publications

References 6 publications

Prevalence and Responsiveness to Treatment of Lung Abnormalities on Chest Computed Tomography in Patients With Microscopic Polyangiitis: A Multicenter, Longitudinal, Retrospective Study of One Hundred Fifty Consecutive Hospital‐Based Japanese Patients

Prevalence and Responsiveness to Treatment of Lung Abnormalities on Chest Computed Tomography in Patients With Microscopic Polyangiitis: A Multicenter, Longitudinal, Retrospective Study of One Hundred Fifty Consecutive Hospital‐Based Japanese Patients

Increasing Global Mortality from Idiopathic Pulmonary Fibrosis in the Twenty-First Century

Idiopathic pulmonary fibrosis: The current status of its epidemiology, diagnosis, and treatment in China

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