Increasing Global Mortality from Idiopathic Pulmonary Fibrosis in the Twenty-First Century

Hutchinson, John; McKeever, Tricia M.; Fogarty, Andrew; Navaratnam, Vidya; Hubbard, Richard

doi:10.1513/annalsats.201404-145oc

Cited by 172 publications

(141 citation statements)

References 16 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…The increasing number of biopsies over time in our study may suggest an increasing desire to characterise ILD, but may simply reflect the rising incidence of ILD in the UK [15,22]. It would be useful to extend our analysis to the present day to assess the impact of the availability of targeted treatments for IPF on rates of biopsy.…”

Section: Discussionmentioning

confidence: 97%

Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997–2008

et al. 2016

Self Cite

View full text Add to dashboard Cite

International guidelines and new targeted therapies for idiopathic pulmonary fibrosis have increased the need for accurate diagnosis of interstitial lung disease (ILD), which may lead to more surgical lung biopsies. This study aimed to assess the risk of this procedure in patients from the UK.We used Hospital Episodes Statistics data from 1997 to 2008 to assess the frequency of surgical lung biopsy for ILD in England, UK. We identified cardiothoracic surgical patients using International Classification of Diseases revision 10 codes for ILD and Office of Population Censuses and Surveys Classification of Interventions and Procedures version 4 codes for surgical lung biopsy. We excluded those with lung resections or lung cancer. We estimated in-hospital, 30-day and 90-day mortality following the procedure, and linked to cause of death using data from the UK Office of National Statistics.We identified 2820 patients with ILD undergoing surgical lung biopsy during the 12-year period. The number of biopsies increased over the time period studied. In-hospital, 30-day and 90-day mortality were 1.7%, 2.4% and 3.9%, respectively. Male sex, increasing age, increasing comorbidity and open surgery were risk factors for mortality.Surgical lung biopsy for ILD has a similar mortality to lobectomy for lung cancer, and clinicians and patients should understand the likely risks involved. @ERSpublications 30-day mortality after surgical lung biopsy for ILD is 2.4% (similar to lobectomy for lung cancer)

show abstract

Section: Discussionmentioning

confidence: 97%

Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997–2008

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…IPF has a median survival of ∼3 years from the time of diagnosis [2,3], and most patients die from progressive respiratory failure [4][5][6][7]. These deaths are frequently precipitated by acute respiratory worsening, including acute exacerbations of IPF (AE-IPF), which are traditionally defined as an acute worsening of dyspnoea and lung function with an unknown aetiology [8].…”

Section: Introductionmentioning

confidence: 99%

Acute exacerbation of idiopathic pulmonary fibrosis: shifting the paradigm

et al. 2015

View full text Add to dashboard Cite

The goal of this review is to summarise the clinical features, management, and prognosis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). AE-IPF has previously been defined based on clinical and radiological features that include the subacute onset of dyspnoea, bilateral ground glass changes on chest high-resolution computed tomography, and the absence of an identifiable aetiology. The annual incidence of AE-IPF is typically reported at 5-15%, but is less common in mild disease. Features of diffuse alveolar damage are present when a biopsy is performed. Idiopathic pulmonary fibrosis (IPF) patients with acute respiratory worsening are often initially treated with high dose corticosteroids and antimicrobials; however, there are no clear data to support these therapies, and the short-term mortality of AE-IPF is ∼50%. Recent studies have shown that the features and prognosis of AE-IPF are similar to other causes of acute respiratory worsening, including infection, aspiration, air pollution and mechanical injury to the alveolar epithelium. Based on this emerging evidence, we propose a novel approach to the classification of acute respiratory worsening events in patients with IPF that focuses on clinical and radiological findings consistent with an underlying pathobiology of diffuse alveolar damage. @ERSpublications A review summarising the features, management, and prognosis of acute exacerbations of idiopathic pulmonary fibrosis

show abstract

“…A similar incidence, 9 cases per 100 000, was reported in Canada using a narrow definition of IPF [3]. The age-adjusted mortality rate for IPF ranges from 2 to 10 per 100 000, resulting in an estimated 30 000-60 000 deaths in Europe in 2014 [4]. Despite the large number of individuals impacted by this nominally rare disease, there has been only one intervention proven to increase life expectancy in IPF and that is lung transplantation [5].…”

mentioning

confidence: 66%

Toward understanding patient experience in idiopathic pulmonary fibrosis

Danoff

2017

Eur Respir J

View full text Add to dashboard Cite

Increasing Global Mortality from Idiopathic Pulmonary Fibrosis in the Twenty-First Century

Cited by 172 publications

References 16 publications

Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997–2008

Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997–2008

Acute exacerbation of idiopathic pulmonary fibrosis: shifting the paradigm

Toward understanding patient experience in idiopathic pulmonary fibrosis

Contact Info

Product

Resources

About