Idiopathic pulmonary fibrosis in Taiwan – A population-based study

Abstract

In Taiwan, elderly men were the major group suffering from IPF. Survival time was short after IPF diagnosis, and the poor survival was largely attributable to quick IPF progression after diagnosis.

Increasing Global Mortality from Idiopathic Pulmonary Fibrosis in the Twenty-First Century

“…For example, the contrast between the proportion of deaths due to 'unspecified' interstitial lung disease in Japan (70-75%) and elsewhere (10-20%) warrants further exploration. Previous literature has suggested a lower incidence of IPF in East Asia (19,20) although this likely relates to sampling of insurance databases featuring mainly severe disease. Assessment of data from other countries in East…”

[Nintedanib for the treatment of idiopathic pulmonary fibrosis in Italy]

“…La IPF rimane una patologia a prognosi infausta [13], con una sopravvivenza mediana di circa 2-3 anni dalla diagnosi [6,14,15] ed una sopravvivenza a 5 anni del 20-40% [16]. Tale prognosi sfavorevole può essere correlabile al ritardo nella diagnosi e alla bassa disponibilità di terapie specifiche [5]. Una proporzione di pazienti con IPF compresa tra il 40% e il 70% dei pazienti affetti muore a causa della progressione [5,17].…”

“…Tale prognosi sfavorevole può essere correlabile al ritardo nella diagnosi e alla bassa disponibilità di terapie specifiche [5]. Una proporzione di pazienti con IPF compresa tra il 40% e il 70% dei pazienti affetti muore a causa della progressione [5,17]. Le riacutizzazioni acute della IPF, il motivo più frequente di rapido deterioramento [14], inducono un repentino declino della funzionalità polmonare e contribuiscono all'insorgenza dell'insufficienza respiratoria, una delle principali cause di mortalità [6,18].…”

Idiopathic pulmonary fibrosis: another step in understanding the burden of this disease

“…In general, early studies tended to involve clinicians collating cases from their local area [3,4] or asking interested colleagues to contribute to registries [5,6], whereas later studies have made use of large databases collected for clinical care or administrative reasons [7][8][9][10]. These later studies boasted far greater numbers, though with some concern about the validity of the cases, the reliability of clinical coding and generalisability to the wider population.…”

“…The authors used two data sources to identify cases: a mandatory nationwide database of hospital admissions, and a smaller database of emergency department and outpatient clinic attendances covering ∼50% of the national population. Incident and prevalent cases were identified with both "broad" and "narrow" definitions of IPF, as with other studies [7,9]: the latter more specific definition requiring the presence of a relevant diagnostic test (computed tomography, lung biopsy or bronchoscopy) prior to the record with the diagnostic code for IPF.…”