Idiopathic Myelofibrosis Followed by Acute Lymphoblastic Leukemia

Marino, Robert

doi:10.1001/archpedi.1979.02130110102022

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…The vast majority of these cases have documented the myelofibrosis in the context of a systemic infection or malignancy. The diagosis of idiopathic myelofibrosis in such situations can pose problems, because the fibrosis can antedate malignant events by weeks to months (Marino et al, 1979). Most reports describe an aggressive course and a high mortality, although more recently Reid et al (1988) and others have documented children with myelofibrosis with a less aggressive course.…”

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confidence: 99%

Idiopathic myelofibrosis in children

et al. 1996

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Childhood myelofibrosis (Mf) is rare with variable outcome reported in the literature. We present clinical and investigate details of three children who presented with idiopathic Mf in early childhood. Two of these children were identical twins and have been haematologically stable over the past 7 years since their diagnosis. The third patient underwent an allogeneic bone marrow transplant (BMT) procedure as her clinical status was deteriorating. She remains engrafted at 13 months post BMT. None of the children had hepatosplenomegaly although extramedullary haemopoiesis was demonstrated on 52Fe studies in two patients. Circulating progenitors in these patients were increased in the face of reduced marrow precursors. The aetiology of childhood Mf is unclear and its natural history seems different from the adult disease. Allogeneic BMT can be an option for definitive treatment.

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confidence: 99%

Idiopathic myelofibrosis in children

et al. 1996

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“…In the larger series of MF [2,[4][5][6] totalling 338 patients, young adults under 40 years were a rarity, with virtually no patients under 30. Al though scattered case reports of MF in the pediatric age-group have been reported [8,9], the disease in these patients had an ag gressive, rapidly progressive course sug gestive of the acute form of the myelo fibrosis-malignant myelosclerosis syn drome [10]. During a follow-up period of 4-5 years, the clinical course of our pa tients has remained stable (cases 1, 3), or very slowly progressive (case 2).…”

Section: Discussionmentioning

confidence: 67%

Myelofibrosis in Young Adults

Shalev¹,

Goldfarb²,

Ariel

et al. 1983

Acta Haematol

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“…We conducted a PubMed search using the key words "acute myelofibrosis" and "acute lymphoblastic leukemia" and found 11 articles (12 cases) describing an association of MF with ALL [2][3][4][5][6][7][8][12][13][14][15]. However, full-texts of only nine articles were accessible [2,[4][5][6][7][8][13][14][15]. Four patients did not have AMF and their clinical or pathological findings were consistent with the diagnosis of PMF (two patients: tear drop cells and two patients: hepatosplenomegaly) [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…However, full-texts of only nine articles were accessible [2,[4][5][6][7][8][13][14][15]. Four patients did not have AMF and their clinical or pathological findings were consistent with the diagnosis of PMF (two patients: tear drop cells and two patients: hepatosplenomegaly) [13][14][15]. Thus, only seven cases of AMF with ALL (pediatric: 4 and adult: 3) have been reported till date (Table 1) [2][3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%