Idiopathic hypogonadotropic hypogonadism in a male runner is reversed by clomiphene citrate

Burge, Mark R.; Lanzi, Richard A.; Skarda, Shayne; Eaton, R. Philip

doi:10.1016/s0015-0282(97)81384-2

Cited by 42 publications

(17 citation statements)

References 4 publications

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“…Tenover et al also found an improvement in serum levels of T in a group of ten men using chronic CC (6). The appeal of CC in the treatment of functional hypogonadotropic hypogonadism in males lies in the re-establishment of physiologic hypothalamic-pituitary-gonadal feedback regulation and function (20). Guay et al had good results over libido and erections when their 173 patients used 50mg 3 times a week.…”

Section: Discussionmentioning

confidence: 98%

Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study

Ros

Averbeck

2012

Int. braz j urol.

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Section: Discussionmentioning

confidence: 98%

Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study

Ros

Averbeck

2012

Int. braz j urol.

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“…In addition, there is already a small literature on CC in male adult-onset IHH. Burge et al (22) reported complete reversal of severe IHH for 5 months in an osteoporotic male endurance runner with 50 -100 mg/d of CC.…”

Section: Ioannidou-kadis Adult-onset Hypogonadotropic Hypogonadism mentioning

confidence: 99%

Complete reversal of adult-onset isolated hypogonadotropic hypogonadism with clomiphene citrate

Ioannidou-Kadis

Wright²,

Neely

et al. 2006

Fertility and Sterility

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“…Low energy availability is caused by insufficient food intake and excessive exercise energy expenditure. Similarly, a previous study reported that male endurance athletes suffered from low bone mineral density (BMD) accompanied by low energy availability (7).…”

mentioning

confidence: 93%

Food Restriction Causes Low Bone Strength and Microarchitectural Deterioration in Exercised Growing Male Rats

Hattori

Park

Agata

et al. 2014

J Nutr Sci Vitaminol

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SummaryThe pathogenesis of bone disorders in young male athletes has not been well understood. We hypothesized that bone fragility is caused by low energy availability, due to insufficient food intake and excessive exercise energy expenditure in young male athletes. To examine this hypothesis, we investigated the influence of food restriction on bone strength and bone morphology in exercised growing male rats, using three-point bending test, dualenergy X-ray absormetry, and micro-computed tomography. Four-week-old male SpragueDawley rats were divided randomly into the following groups: the control (Con) group, exercise (Ex) group, food restriction (R) group, and food restriction plus exercise (REx) group after a 1-wk acclimatization period. Thirty-percent food restriction in the R and REx groups was carried out in comparison with that in the Con group. Voluntary running exercise was performed in the Ex and REx groups. The experimental period lasted 13 wk. At the endpoint of this experiment, the bone strength of the femurs and tibial BMD in the REx group were significantly lower than those in the Con group. Moreover, trabecular bone volume and cortical bone volume in the REx group were also significantly lower than those in the Con group. These findings indicate that food restriction causes low bone strength and microarchitectural deterioration in exercised growing male rats.

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Idiopathic hypogonadotropic hypogonadism in a male runner is reversed by clomiphene citrate

Cited by 42 publications

References 4 publications

Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study

Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study

Complete reversal of adult-onset isolated hypogonadotropic hypogonadism with clomiphene citrate

Food Restriction Causes Low Bone Strength and Microarchitectural Deterioration in Exercised Growing Male Rats

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