Complete reversal of adult-onset isolated hypogonadotropic hypogonadism with clomiphene citrate

Ioannidou-Kadis, S; Wright, P. J.; Neely, RD; Quinton, Richard

doi:10.1016/j.fertnstert.2006.03.065

Cited by 21 publications

(14 citation statements)

References 23 publications

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“…We also noticed the effects of clomiphene citrate in restoring the level of testosterone significantly after the administration of clomiphene citrate even before the replacement of testosterone was started, which supports results reported earlier (Guay et al. , 2003; Ioannidou‐Kadis et al. , 2006).…”

Section: Discussionsupporting

confidence: 91%

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An unusual case of vascular hypogonadism treated with clomiphene citrate and testosterone replacement

2009

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Many male patients are discovered on screening to suffer from hypogonadism and age related hypogonadism is being increasingly recognized. However, secondary causes of hypogonadism should not be overlooked, especially in patients who may have concomitant morbidity as highlighted in this case. Our patient with vascular hypogonadism was treated with testosterone and clomiphene citrate in cycles; with a hope of improving not only androgen levels but overall pituitary function as there were co-existing endocrine pathologies of albeit primary hypothyroidism and low IGF-1 levels. Treatment with exogenous testosterone is fairly well established; but there is also increasing evidence of the effectiveness and short-term safety of clomiphene citrate in restoring not only biological levels but functional states in males as well. As such, we report an unusual case of a patient seen at our Men's Health & Andrology clinic in which both the cause of some otherwise unremarkable symptoms and the treatment, using a combination of clomiphene citrate and testosterone, were remarkable.

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Section: Discussionsupporting

confidence: 91%

“…The pathological process in this case was irreversible (Guay et al. , 2003; Ioannidou‐Kadis et al. , 2006).…”

Section: Discussionmentioning

confidence: 74%

An unusual case of vascular hypogonadism treated with clomiphene citrate and testosterone replacement

2009

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“…The authors noted similar improvements in hormone levels and sexual function. 21 A case series of men with HH included four men with idiopathic HH who were treated with CC 50 mg three times weekly for 3 months. 15 Three out of the four men achieved significant improvement in FSH, LH, testosterone, and semen parameters and two fathered pregnancies.…”

Section: Clomiphene Citrate For Hypogonadismmentioning

confidence: 99%

Clomiphene Citrate in the Management of Male Infertility

Roth¹,

Ryan²,

Meacham

2013

Semin Reprod Med

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Clomiphene citrate, a selective estrogen receptor modulator, has been used to treat infertility in women and men for 50 years. In men, clomiphene citrate has been employed in the management of unexplained infertility, oligo and asthenospermia, hypogonadism, and nonobstructive azoospermia. The available evidence reveals mixed results and suggests that clomiphene citrate may be appropriate for the management of male infertility in specific clinical scenarios. Further research is needed to clarify when clomiphene citrate is indicated in the treatment of male infertility.

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“…It competes with estradiol for the estrogen receptors at the level of the hypothalamus and blocks the normal negative feedback mechanism of circulating estradiol on the hypothalamus, preventing estrogen from limiting the production of GnRH. The increase in GnRH level then stimulates the pituitary gland to release more FSH and LH, resulting in an increase in sperm and T production by the testes (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study

Ros

Averbeck

2012

Int. braz j urol.

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Complete reversal of adult-onset isolated hypogonadotropic hypogonadism with clomiphene citrate

Cited by 21 publications

References 23 publications

An unusual case of vascular hypogonadism treated with clomiphene citrate and testosterone replacement

An unusual case of vascular hypogonadism treated with clomiphene citrate and testosterone replacement

Clomiphene Citrate in the Management of Male Infertility

Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study

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