Idiopathic Hypochromemia

Mills, Edward S.

doi:10.1097/00000441-193110000-00010

Cited by 16 publications

(2 citation statements)

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“…In one clinical study with infants, Mills reported that Cu supplements accelerated hemoglobin synthesis in hypochromic anemia of infants treated with Fe salts [11]. Idiopathic hypochromenia in adults was also shown to respond to Fe and Cu in combination [12]. Rigorous confirmation by Keil and Nelson showed that Cu and no other mineral element worked with Fe to restore hemoglobin to the blood [13].…”

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confidence: 99%

Copper and Iron: A landmark connection of two essential metals

Harris

2001

J Trace Elements Exper Med

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Research in the past millennium gave us formidable advances in the fields of Cu nutrition, biochemistry, animal and human health. Insights into Cu‐Fe interactions highlighted much significant advancement. The recognition that Cu was an essential mineral for Fe metabolism and hemoglobin biosynthesis traces back to a paper by Hart et al. at Wisconsin appearing in the first third of the century. This observation came at a time when the only known function of Cu was that of a constituent of hemocyanin pigment in some mollusks and crustacea. The Wisconsin group's studies were preceded by McHargue's work, which introduced glass‐lined cages to study trace mineral function, and in so doing, provided the first experimental evidence for Mn, Cu, and Zn essentiality. Here, we review the details of the experiments by Hart et al. that led to the discovery of copper's interconnection with Fe and important papers that have since given mechanistic clarity to the interaction. J. Trace Elem. Exp. Med. 14:207–210, 2001.

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confidence: 99%

Copper and Iron: A landmark connection of two essential metals

Harris

2001

J Trace Elements Exper Med

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“…Hunter (7) Mills (16), Davies (17), and VanderHoof and Davis (18)) believe that this syndrome is a specific disease and that the anacidity is an important etiological factor. However, Bloomfield (19) has critically reviewed the subject and pointed out that various degrees of anemia may be associated with anacidity and that all types of gastric secretion may be associated with anemia.…”

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confidence: 99%