Idiopathic collapsing glomerulopathy in children

Abstract

Collapsing glomerulopathy is an aggressive variant of focal segmental glomerulosclerosis. All patients with CG should be screened for the underlying etiology, and patients with idiopathic CG should be offered a trial of immunosuppressive therapy.

Collapsing Focal Segmental Glomerulosclerosis in a Young Child

“…Collapsing FSGS has been described by many authors from different parts of the world as a cause of SRNS in children [9,12,13,14]. Our patient had high blood pressure at presentation, and this is similar to previous reports of initial high blood pressure in affected children [13].…”

“…In general, there is a poor response to steroids [12,13,14]. However, remission is achievable in some patients with other immunosuppressive therapy [14,15,16].…”

Collapsing FSGS: a clinicopathologic study of 10 cases from Pakistan

“…These studies have established this pattern of glomerular injury as a clinically and pathologically distinct variant of FSGS and not as a separate clinicopathologic entity [18][19][20][21][22][23][24][25][26][27][28]. All the later studies have reported a similar rapidly progressive course to renal failure in patients with collapsing FSGS who lack HIV-1 infection [18][19][20][21][22][23][24][25][26][27][28]. Collapsing FSGS is less commonly reported from Europe [20,21] and only occasional cases are reported from tropical countries [27,28].…”

“…Since then, Fibrointimal thickening of arteries a 1 1 5 6 9 2 2 0 2 3 -2 2 1 1 3 22 3 19 3 2 0 4 5 -1 3 1 0 5 27 -11 2 1 1 6 16 -13 a number of studies on this lesion have appeared in the medical literature, mostly from the United States, predominantly in the form of case reports or small series [17][18][19][20][21][22][23][24][25][26][27][28]. These studies have established this pattern of glomerular injury as a clinically and pathologically distinct variant of FSGS and not as a separate clinicopathologic entity [18][19][20][21][22][23][24][25][26][27][28]. All the later studies have reported a similar rapidly progressive course to renal failure in patients with collapsing FSGS who lack HIV-1 infection [18][19][20][21][22][23][24]…”

“…One of the pathological variants of FSGS, the collapsing type, is of particular interest because of its increasing incidence, frequent association with black race, HIV-1 infection, and IV drug abuse [16][17][18][19][20][21][22][23][24][25][26]. Collapsing FSGS is uncommonly reported from the tropics [27,28]. Until now, no detailed clinicopathologic analysis of this lesion has been reported from Pakistan.…”