Idiopathic central retinal artery occlusion in an eight-year-old girl

Antoun, Joëlle; Slim, Élise; Hemade, Adib; Awada, Sanaa; Fakhoury, Henry; Cherfan, Carole G.

doi:10.1016/j.jfo.2015.04.016

Cited by 3 publications

(5 citation statements)

References 8 publications

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“…There are few similar published cases healthy children in the literature. [5][6][7][8] The original series by Brown et al included 6 patients in this age range; however, only 1 was absent a known history of sickle cell disease or trauma. 1 Ratra and Dhupper identified 4 patients less than 18, 2 of whom had elevated ESR of uncertain etiology, and 2 of whom had no abnormalities.…”

Section: Discussionmentioning

confidence: 99%

“…3 Since then we identified only a handful of similar cases in this age range in the published literature, which most commonly are suspected to be complications of underlying viral or atypical mycobacterial infections. [5][6][7][8] There is no treatment proven to improve the visual outcome in RAO. Interventions such as ocular massage, anterior chamber paracentesis, intra-arterial thrombolysis have been attempted and if utilized emergently may improve the prognosis for embolic RAO; however, the rarity of these cases prevent evidence-based recommendations.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Retinal Artery Occlusions in Healthy Children

Sundy¹,

Malihi²,

Chang

et al. 2017

Journal of VitreoRetinal Diseases

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To describe a series of retinal arterial occlusions in healthy children. Methods: Chart review from multiple US and international institutions. Results: Five episodes affecting otherwise healthy children aged 5 to 14 are described. With the exception of migraine history in 1 individual and a novel heterozygous mutation of uncertain significance in 1 patient without clinical hyper-homocysteinemia in the methylenetetrahydrofolate reductase gene, no risk factors or systemic pathology contributing to the event were identified. Conclusion: We report a series of unilateral retinal artery occlusions in otherwise healthy children. This devastating ocular disease typically elicits an extensive ophthalmologic, radiologic, hematologic, and cardiologic evaluation, which is often unrevealing in this population. There are no evidence-based guidelines to guide the extent of diagnostic evaluation or management. Sequential bilateral artery occlusions have never been reported in otherwise healthy children.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Retinal Artery Occlusions in Healthy Children

Sundy¹,

Malihi²,

Chang

et al. 2017

Journal of VitreoRetinal Diseases

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“…Curative effects could be classified into four levels on the basis of the situations of visual acuity, fundus oculi and visual field as: cured, markedly effective, effective and ineffective, respectively. Cured indicated that the visual acuity improved by 4 lines or more in the logarithmic visual acuity chart or the visual acuity improved by less than 4.8; no edema existed in the retina of fundus oculi; and the scope of visual field defect reduced by >50% or the visual field returns to normal on the whole ( 2 , 21 , 23 – 25 ). Markedly effective indicated that the visual acuity improved by >3 lines; ischemia of fundus oculi improved basically, and the scope of visual field defect decreased by 30–40%.…”

Section: Methodsmentioning

confidence: 99%

“…At present, conventional methods including oxygen inhalation, eyeball massage, tube expansion and anticoagulation are mostly used in clinics, and auxiliary medicine such as vitamin B and energy are administered simultaneously. The curative effects generally fail to be satisfactory ( 2 ). Urokinase artery intervention thrombolysis is an emergent technology in the recent decade and is widely used in China.…”

Section: Introductionmentioning

confidence: 99%

Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion

Gao

Liu

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the present study was to observe the clinical efficacy and safety of recombinant tissue plasminogen activator (rt-PA) combined with compound anisodine in treating central retinal artery occlusion (CRAO). Forty-eight patients diagnosed with CRAO were randomly divided into a treatment group (24 cases) and a control group (24 cases). For the control group, nitroglycerin, 654-2, methazolamide, puerarin and compound anisodine were used for the treatment, along with oxygen, massage and other conventional treatments. Besides conventional therapy, the treatment group was also given intravenous rt-PA thrombolysis. Visual acuity, fundus oculi, visual field changes were taken as indicators for efficacy evaluation. It was found that the total effective rate of the control group was 70.83%, while that for the treatment group was 91.67%, and the comparative difference between the two groups was of statistical significance (p<0.05). The visual field defect of the control group after treatment was approximately 74.26±12.91%, and the visual field defect of the treatment group after treatment approximately 35.08±16.33%; thus, the comparative difference was statistically significant (p<0.01). The comparative difference of the original contents of fibrous protein in blood in the treatment group before and after treatment was statistically significant (p<0.01). In conclusion, the result show that intravenous thrombolysis with rt-PA combined with compound anisodine is safe and effective in treating CRAO, which can significantly improve the prognosis of patients.

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