14th EUNOS Congress

Glebauskiene, Brigita; Liutkevičienė, Rasa; Varoniukaitė, Aistė

doi:10.1080/01658107.2019.1608780

Cited by 2 publications

(1 citation statement)

References 353 publications

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“…Технология SWEPT-source позволяет визуализировать все слои хориоидеи, а также в автоматическом режиме распознавать ее границы и строить карты с определением толщины в каждом секторе в проекции макулярной зоны сетчатки [43,44]. Публикации последних лет показывают перспективность широкого внедрения технологии SWEPT-source в клиническую практику для анализа различных патологических состояний с вовлечением сосудистой оболочки глаза [45][46][47][48][49][50][51][52]. Основной тенденцией развития метода ОКТА в диагностической офтальмологии будет применение мультимодального подхода для оценки состояния глазного дна, включающего сочетанное применение микропериметрии и других визуализационных методов диагностики.…”

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Optical coherence tomography-angiography as a non-invasive method of pathology diagnosis of the microcirculatory bed of the optic nerve and macula

Krivosheeva¹,

Иойлева

2021

Rossijskij oftalʹmologičeskij žurnal

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Optical coherence tomography-angiography as a non-invasive method of pathology diagnosis of the microcirculatory bed of the optic nerve and macula

Krivosheeva¹,

Иойлева

2021

Rossijskij oftalʹmologičeskij žurnal

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Changes in Visual Function and Correlations with Inner Retinal Structure in Acute and Chronic Leber’s Hereditary Optic Neuropathy Patients after Treatment with Idebenone

Pemp

Mitsch

Kircher

et al. 2021

JCM

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Progressive impairment and degeneration of retinal ganglion cells (RGC) and nerve fibers in Leber’s hereditary optic neuropathy (LHON) usually cause permanent visual loss. Idebenone is currently the only approved treatment. However, its therapeutic potential in different stages of LHON has not been definitely clarified. We aimed to investigate the changes in visual function and correlations with retinal structure in acute and in chronic LHON patients after treatment with idebenone. Twenty-three genetically confirmed LHON patients were followed during treatment using logMAR charts, automated perimetry and optical coherence tomography (OCT). Mean visual acuity improved significantly in acute patients treated within 1 year from onset (−0.52 ± 0.46 logMAR from nadir), in early chronic patients who started after 1–5 years (−0.39 ± 0.27 logMAR from baseline), and in late chronic patients with treatment initiation after >5 years (−0.33 ± 0.28 logMAR from baseline, p < 0.001 all groups). In acute and in chronic patients, strong correlations between OCT and visual function parameters were present only after treatment. This and the sustained visual recovery after treatment may indicate a reactivated signal transduction in dysfunctional RGC that survive the acute phase. Our results support previous evidence that idebenone has therapeutic potential in promoting visual recovery in LHON.

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14th EUNOS Congress

Cited by 2 publications

References 353 publications

Optical coherence tomography-angiography as a non-invasive method of pathology diagnosis of the microcirculatory bed of the optic nerve and macula

Optical coherence tomography-angiography as a non-invasive method of pathology diagnosis of the microcirculatory bed of the optic nerve and macula

Changes in Visual Function and Correlations with Inner Retinal Structure in Acute and Chronic Leber’s Hereditary Optic Neuropathy Patients after Treatment with Idebenone

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