Idiopathic CD4+ T-Lymphocytopenia with Bowen's Disease.

Hayashi, Toshiaki; Hinoda, Yuji; Takahashi, Tohru; Adachi, Masaaki; Miura, Satoshi; Izumi, Toshihiko; Kojima, Hiroyuki; Yano, Shoki; Imai, Kohzoh

doi:10.2169/internalmedicine.36.822

Cited by 16 publications

(10 citation statements)

References 16 publications

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“…These are important results because this ratio is used in the evaluation of immunosuppression status in patients with several pathologies, such as cancer. Indeed, Hayashi et al (23) reported that the Th/Tc cell ratio was decreased in adults with Bowen's disease (squamous cell carcinoma in situ), a form of cancer that can be caused by arsenic ingestion. Moreover, a similar decrease in Th/Tc ratio as that obtained in this study has been reported in several pathologies, such as Kaposi's sarcoma (24), melanoma (25), skin carcinoma (26), and in association with HIV infection (27).…”

Section: Discussionmentioning

confidence: 99%

Assessment of lymphocyte subpopulations and cytokine secretion in children exposed to arsenic

Soto-Peña¹,

Luna²,

et al. 2006

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Exposure of several human populations to arsenic has been associated with a high incidence of detrimental dermatological and carcinogenic effects. To date, studies examining the immunotoxic effects of arsenic in humans, and specifically in children, are lacking. Therefore, we evaluated several parameters of immunological status in a group of children exposed to arsenic through their drinking water. Peripheral blood mononuclear cells (PBMCs) of 90 children (6 to 10 years old) were collected. Proportions of lymphocyte subpopulations, PBMC mitogenic proliferative response, and urinary arsenic levels were evaluated. Increased urine arsenic levels were associated with a reduced proliferative response to phytohemaglutinin (PHA) stimulation (P=0.005), CD4 subpopulation proportion (P=0.092), CD4/CD8 ratio (P=0.056), and IL-2 secretion levels (P=0.003). Increased arsenic exposure was also associated with an increase in GM-CSF secretion by mononucleated cells (P=0.000). We did not observe changes in CD8, B, or NK cell proportions, nor did we observe changes in the secretion of IL-4, IL-10, or IFN-gamma by PHA-activated PBMCs. These data indicate that arsenic exposure could alter the activation processes of T cells, such that an immunosuppression status that favors opportunistic infections and carcinogenesis is produced together with increased GM-CSF secretion that may be associated with chronic inflammation.

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Section: Discussionmentioning

confidence: 99%

Assessment of lymphocyte subpopulations and cytokine secretion in children exposed to arsenic

Soto-Peña¹,

Luna²,

et al. 2006

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“…The symptoms varied and included pruritus, erythroderma, 42 vesicles, warts, verrucous papules and plaques, 79 condylomata, 80 and mycetoma (Exophiala jeanselmei and M. chelonae). 52 Infection of the skin included viral, bacterial, fungal and parasitic infections like herpes zoster, HPV, 80 molluscum contagiosum, 59 Stenotrophomonas maltophilia, 53 MAC, 51 Candida albicans, tinea corporis, 60 tinea pedis, 68 cryptococci, 8 Aureobasidium species, Alternaria species, and Hortaea werneckii, leishmaniasis. 49 Premalignant lesions (vulval intraepithelial neoplasia, Bowen disease) and malignancies (e.g., Kaposi sarcoma, 61 squamous cells carcinoma and basal cell carcinoma) have been reported.…”

Section: Infectionsmentioning

confidence: 99%

<p>Idiopathic CD4 Lymphocytopenia: Current Insights</p>

Vijayakumar¹,

Viswanathan²,

Aghoram³

2020

ITT

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Idiopathic CD4 lymphocytopenia is a condition characterized by low CD4 counts. It is rare and most of the information about this illness comes from case reports. Presentation is usually in the 4th decade of life with opportunistic infections, autoimmune disease or neoplasia. The pathophysiology of this condition is not well understood. Management revolves around treatment of the presenting condition and close follow-up of these patients. This review presents a narrative summary of the current literature on idiopathic CD4 lymphocytopenia.

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“…[9][10][11][12][13] Today in the ART era, treated patients live much longer with low-grade CD4 lymphopenia. Cell-mediated immunity defects are not caused solely by lymphopenia.…”

Section: Mechanism Of Increased Riskmentioning

confidence: 99%